欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
目的 了解地中海贫血（地贫）患儿合并缺铁性贫血（IDA）时血液学各指标的变化,为临床治疗和筛查提供理论依据。方法 通过外周血细胞计数和毛细管电泳筛查确定可疑阳性患儿,采用反向点杂交（RDB）和跨越缺口PCR（Gap-PCR）方法确定初筛阳性患儿的基因突变类型。同时应用化学发光方法检查患儿的血清铁蛋白情况。利用统计学方法比较单纯地贫患儿与地贫复合IDA患儿以及单纯缺铁患儿在血液学各参数上的差异。结果 静止型地贫或轻型地贫复合IDA后会加重地贫患儿的症状,中重度地贫患儿在其复合缺铁后血液学指标改变并不明显。结论 应该关注地贫患儿的缺铁情况,达到有效预防,合理治疗目的。
英文摘要：
Objective To explore the changes of hematologic parameters of thalassemia accompanied with iron deficiency anemia in children, and provide theoretical basis for clinical treatment and screening. Methods To screen the suspected patients by blood count and capillary electrophoresis, and then confirm the thalassemia genotype with RDB and GAP-PCR. At the same time chemiluminescence method was applied to detect the serum ferritin. Statistical method was used to compare differences of each parameter in thalassemia, thalassemia accompanied with IDA, and IDA. Results When the silence and minor thalassemia were accompanied with iron deficiency anemia, the symptoms could get worse. However, thalassemia intermedia and major were not obvious. Conclusions In clinical work we should pay attention to the situation of thalassemia patients with IDA to achieve effective prevention and reasonable treatment.
同期刊论文项目
同项目期刊论文
期刊信息
位置：