中文摘要：

肿瘤转移是恶性肿瘤的主要特征,是临床上癌症患者的主要致死原因,但其具体的分子机制及相关调控网络尚不完全清楚。长链非编码RNA（long non-coding RNA,lncRNA）是指长度大于200个核苷酸、无蛋白编码功能的RNA。已有报道lncRNA作为致癌基因或抑癌基因调控下游靶基因的表达,并从不同方面影响肿瘤细胞的生物学行为,对肿瘤的发生发展产生促进或抑制作用。本文就lncRNA在肿瘤转移中的作用及机制研究的最新进展作一综述,旨在寻找与肿瘤转移密切相关的生物标志物,以期用于肿瘤转移的早期诊断、疗效判断、预后预测乃至基因靶向治疗。

英文摘要：

Tumor metastasis,a main characteristic of malignant tumor,is the major cause of cancer death. However, the molecular mechanism of tumor metastasis is poorly understood although intensively investigated. Recently, long non- coding RNAs（ lnRNAs） have been emerging at the forefront of cancer biomarker and therapeutic target research. LncRNAs are non- protein coding RNAs that are longer than 200 nucleotides. It has been reported that lncRNAs may function as either oncogenes or tumor suppressors to affect tumor development and metastasis through regulation of target gene expression. This article reviews the recent progress in studying the roles and mechanisms of lncRNAs on tumor metastasis.