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中文摘要：
来源于Penicillium chrysongenum的碱溶性（1→3）-α-D-葡聚糖与缩水甘油基三甲基季铵盐酸盐（glycidyltri methylammonium chloride，GTMAC）反应，生成葡聚糖季铵盐。IR图谱中季铵基团上的甲基的变角振动峰1480cm-1、伸缩振动峰2872cm-1变化明显，1H-NMR表征确定季铵基团在糖环2、4位连接。该葡聚糖的最低抑菌浓度对大肠杆菌为1.0 mg/mL，对金黄色葡萄球菌为2.0 mg/mL。细胞质释放检测结果显示，葡聚糖季铵盐通过作用于细菌细胞膜而发挥抗菌作用。
英文摘要：
Quaternary ammonium-glucan has been synthesized by the reaction between glycidyl trimethylammonium chloride （GTMAC） and alkali soluble （1→3）-a-D-glucan isolated from Penicillium chrysongenum. Quaternary ammonium-glucan showed a methyl C→H bending vibration at 1480cm^-1 and stretching vibration at 2872 cm^-1 in its IR spectrum. The quaternary ammonium group is linked with the 3-and 4-positions in the glucose ring according to ^1H-NMR experiments. The minimum inhibitory concentrations （MIC） of quaternary ammonium-glucan were 2.0 mg/mL and 1.0 mg/mL for Staphylococcus aureus.ATCC 6538 and Escherichia coli ATCC8099, respectively. The antibacterial action is associated with an interaction with the cell membrane.
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