中文摘要：

研究者在50年前提出“成体肝组织内存在肝干细胞”这一假说.肝干/祖细胞研究对干细胞基础研究及其临床治疗研究都有着重要的意义.研究者也已从损伤的人类和啮齿动物的肝组织中分离到激活的肝干/祖细胞,并建立了相应的培养体系.目前的研究表明,肝内存在多个具有干细胞特性的细胞,且它们位于肝内不同的区域.另外,潜在的肝干/祖细胞的分子表达谱也已得到一定的阐述.本文结合肝干/祖细胞的研究,对成体肝干/祖细胞的潜在类型、来源与定位作一回顾.

英文摘要：

The existence of hepatic stem cells in adult livers was hypothesized about 50 years ago. Studies on hepatic stem/progenitor cells are an important part in stem cell research and bearing significant values in clinical applications, Activated hepatic stem/progenitor cells have been successfully isolated from injured human or rodent livers, and were cultured in established with corresponding culture system, Several cell types with stem-like properties have been identified, and they resided in the different locations in adult livers. The gene expression profiles of these potential hepatic stem/progenitor cells were also being characterized, This review will focus on the origin, potential types and tissue locations of the adult hepatic stem/progenitor cells.