欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
PTEN是具有磷酸脂酶活性的抑癌基因,是双特异蛋白磷酸酶家族（DSPs）的成员,同时具有脂质磷酸酶和蛋白酪氨酸磷酸酶活性。而在肿瘤增殖,侵袭,迁移的过程中,肿瘤血管生成作为肿瘤发生发展中一个关键因素已越来越受到人们的关注。抑癌基因PTEN可以参与PI3K/Akt信号通路,调控缺氧诱导因子1,基质金属蛋白酶,血管内皮生长因子,钠氢交换调控因子1等血管生成相关信号以及一些机体氧化产物来影响肿瘤血管生成。根据近年来PTEN基因与肿瘤血管生成关系最新研究信息,该文综述了其目前的研究现状。
英文摘要：
PTEN is a tumor suppressing gene with phosphatase activity. It is one of the members of the dual specificity protein phosphatase family （DSPs）. And it has both lipid phosphatase and protein tyrosine phosphatase activity. In the process of tumor proliferation, invasion and migration, increasing attentions have been directed towards tumor angiogenesis as a key factor in tumorigenesis. Tumor suppressing gene PTEN regulates expression of HIF-1, MMPs, VEGF, NHERF-1 and other angiogenesis-related signals and oxidative product by affecting the PI3K/Akt signaling pathway, which further impacts tumor angiogenesis. This article reviews the current research status based on the relationship between PTEN and tumor angiogenesis.
同期刊论文项目
同项目期刊论文
Bioactive tanshinones in Salvia miltiorrhiza inhibit the growth of prostate cancer cells in vitro an
Cryptotanshinone has diverse effects on cell cycle events in melanoma cell lines with different meta
Xanthatin induces cell cycle arrest at G2/M checkpoint and apoptosis via disrupting NF-κB pathway in
Comparative Effects of Hirudo, Frankincense, and Motherwort on Inhibition of Blood Platelet Aggregat
Luteolin reduces the invasive potential of malignant melanoma cells by targeting β3 integrin and the
Inhibition of hypoxia-induced epithelial mesenchymal transition by luteolin in non-small cell lung c
Effect of Aqueous Extracts of Several Kinds of Herbs on Human Platelet Aggregation and Expression of
Chemomodulatory effi cacy of lycopene on antioxidant enzymes and carcinogen-induced cutaneum carcino
Holothurian glycosaminoglycan inhibits metastasis and thrombosis via targeting of nuclear factor-kap
Inhibition of vascular endothelial growth factor-mediated angiogenesis involved in reproductive toxi
Holothurian Glycosaminoglycan Inhibits Metastasis and Thrombosis viaTargeting of Nuclear Factor-κB/T
Concerted Suppressionof STAT3 and GSK3β Is Involved in Growth Inhibition of Non-Small Cell LungCance
CryptotanshinoneActivates p38/JNK and Inhibits Erk1/2 Leading to Caspase-Independent Cell Deathin Tu
Luteolin reduces theinvasive potential of malignant melanoma cells by targeting β3 integrin and thee
Inhibition of hypoxia-induced epithelialmesenchymal transition by luteolin in non-small cell lung ca
The Angiogenic Responses Induced by Release of AngiogenicProteins from Tumor Cell-Activated Platelet
Cryptotanshinone, a novel tumor angiogenesisinhibitor, destabilizes tumor necrosis factor-a mRNA via
Chemopreventive efficacy of menthol on carcinogen-induced cutaneous carcinoma in mice throughinhibit
Cancer-promotingeffect of capsaicin on DMBA/TPA-induced skin tumorigenesis by modulatinginflammation
Holothurian glycosaminoglycan inhibits metastasis via inhibition of P-selectin in B16F10 melanoma ce
PKM2 Regulates Hepatocellular Carcinoma Cell Epithelial-mesenchymal Transition and Migration upon EG
PKM2 Regulates Hepatocellular Carcinoma Cell Epithelialmesenchymal Transition and Migration upon EGF
Phenolcarboxylic acids from medicinal herbs exert anticancer effects through disruption of COX-2 act
期刊信息
位置：