中文摘要：

一灵巧自己组装制作维生素 E-tocopheryl 聚乙烯乙二醇 succinate (TPGS ) 的策略与装载水平的高药基于 nanoparticles 因为多重药的合作交货被开发。到克服的多药抵抗，一个化学疗法的代理人(paclitaxel， PTX ) 并且一个药抵抗禁止者(tariquidar， TQR ) 在维生素 E-TPGS 被共同装载获得 TPGS/PTX/TQR nanoparticles 的基于的 nanoparticle。单音药的装载 TPGS/PTX nanoparticles 和双药的装载 TPGS/PTX/TQR nanoparticles 的尺寸低于 150 ? 有相对狭窄的尺寸分布的 nm。肿瘤房间抑制和药抵抗的颠倒上的药交货系统的效率在药被评估抵抗癌症房间(MCF-7/ADR ) 作为与不抵抗的房间(HeLa ) 相比。由于由 TQR 的 P-gp 流出的有效抑制，显著地展出的双药的装载 nanoparticles 改进了肿瘤房间禁止的效率。学习 immunostimulatory 效果， IL-10 的生产上的药交货系统的效果，与肿瘤开发有关的 cytokine，在这药，抵抗房间被决定。在由药交货系统的治疗以后，在房间上层清液的 IL-10 的集中减少了。多药为 synergistic 药交货装载了维生素 E-TPGS nanoparticles 在肿瘤治疗在药抵抗的颠倒有有希望的应用。

英文摘要：

A facile self-assembly strategy to labricate vitamin E-tocopheryl polyethylene glycol succinate （TPGS） based nanoparticles with a high drug loading level for co-delivery of multiple drugs was developed. To overcome multi-drug resistance, a chemotherapeutic agent （paclitaxel, PTX） and a drug resistance inhibitor （tariq- uidar, TQR） were co-loaded in the vitamin E-TPGS based nanoparticle to obtain TPGS/PTX/TQR nanoparticles. The sizes of mono-drug loaded TPGS/PTX nanoparticles and dual-drug loaded TPGS/PTX/TQR nanoparticles were below 150 nm with relatively narrow size distributions. The efficiencies of the drug delivery systems on tumor cells inhibition and reversal of drug resistance were evaluated in drug resistant cancer cells （MCF-7/ADR） as compared with nonresistant cells （HeLa）. Due to the effective inhibition of the P-gp efflux by TQR, the dual-drug loaded nanoparticles exhibited significantly improved tumor cell inhibitory efficiency. To study the immunostimulatory effect, the effect of the drug delivery system on the production of IL- 10, a cytokine related to tumor development, in the drug resistant cells was determined. After the treatment by the drug delivery systems, the concentration of IL-10 in the cell supernatant decreased. The multi-drug loaded vitamin E-TPGS nanoparticles for synergistic drug delivery have promising applications in reversal of drug resistance in tumor treatments.