中文摘要：

目的：对实验性动脉粥样硬化家兔血清中巨噬细胞移动抑制因子、肿瘤坏死因子、白介素-6含量进行分析,以探讨它们在冠心病发病过程中的意义.方法：研究对象为新西兰大白兔,随机分成对照组（10只）和实验组（10只）.对照组喂食基础饲料,实验组喂食高脂饲料（基础饲料中加入1%胆固醇＋5%猪油）.均喂饲8周后采用ELISA法检测其血清MIF、TNF-α、IL-6水平.结果：组织病理切片结果显示实验组兔主动脉弓内膜增厚,动脉粥样斑块明显.与对照组比较,实验组MIF、TNF-α、IL-6水平均升高,其差别有显著性（p＜0.01）.结论：MIF、TNF-α、IL-6与动脉粥样硬化的发生有密切关系,这些细胞因子可通过相互诱导、相互协同共同参与冠心病的发生、发展过程.

英文摘要：

Objective： To study the roles of MIF （macrophage migration inhibitory factor）, TNF-α and IL-6 in atherosclerosis （AS）. Methods： Twenty New Zealand rabbits were randomly divided into two groups. The rabbits in control group were given basic food and the rabbits in experimental group were given high lipid diet. After 8 weeks, the levels of serum MIF, TNF-and IL-6 were determined by ELISA in the two groups. Results： Histological analyses showed that compared with control group , there were thicker intima in experimental group,in which, the rabbits treated with high lipid created mature atheromatous plaque, with higher levels of MIF, TNF-and IL-6 （p〈0.01）. Conclusion： Rabbits can be used as an ideal model for researching atherosclerosis. There is close relationship between serum MIF, TNF-α and IL-6 levels and development of atherosderosis, which play an important role in the pathogenesis through mutual induction and synergistic actions.