在细菌分析中,发展了很多基因分型技术,包括分析部分基因组信息的脉冲场凝胶电泳、多位点可变串联重复序列分析和差异片段分析技术等,以及基于全基因组信息的比较基因组学技术。在鼠疫菌的研究与应用中,很多技术得到了成功的应用。该研究主要与同期发表的有关鼠疫菌质粒谱的一篇论文和一篇鼠疫菌基因分型的综述相呼应,从实用的角度简述了各基因分型技术在鼠疫菌研究中的应用。
There are different genotyping techniques, including partial genomic information-based methods such as pulsed-filed gel electrophoresis (PFGE), multilocus variable tandem repeat analysis (MLVA), different region(DFR) analysis etc., and whole genome-based comparative genomics, available for bacterial analysis. Many of them have been successfully applied in Yersinia pestis. In accompany with one paper on Yersinia pestis plasmid profiles and one review on genotyping analysis in Yersinia pestis, published in the same issue, this review briefed the different genotyping techniques in focus of their applications.