中文摘要：

胰腺β细胞的氧化还原异常不仅会引起β细胞凋亡,而且对胰岛素加工、分泌以及胰岛素抵抗也有重要的影响。近年来,国内外学者就胰腺β细胞氧化还原状态对胰岛素加工、分泌的影响及调控机制开展了大量的研究,取得了丰硕的成果,为2型糖尿病的防治提供了新思路和靶点。该文拟就胰岛素加工、分泌与细胞氧化还原状态的关系进行综述,以期进一步了解、认识2型糖尿病的发生和发展。

英文摘要：

A growing body of evidence suggests that redox imbalance plays an essential role in pancreatic β cells, which does not only induce the cellular apoptosis, but also affects the processing and secretion of insulin. Recently, great progress has been made in understanding the mechanism and regulation of redox balance on the processing of insulin and glucose-stimulated insulin secretion, which supplies some new ideas and targets for the treatment of type 2 diabetes mellitus. Herein, we try to summarize the development about the effects of redox state on the processing and secretion of insulin, and as for a further comments to understand the formation and development of type 2 diabetes mellitus.