中文摘要：

目的：多巴胺（DA）是中枢神经系统（CNS）中最重要的儿茶酚胺类神经递质之一,在调节大脑的运动、认知、情感、正性强化、摄食和内分泌等诸多功能中发挥重要作用。DA与帕金森氏病、精神分裂症、抽动秽语综合征、药物成瘾、学习和记忆缺陷、注意力缺陷多动综合征等精神神经疾病的发病机制密切相关。大量研究表明DA在调节突触可塑性方面有很重要的作用,尤其是DA五种受体发现后,研究人员应用受体不同的激动剂和阻断剂研究DA的功能,更具体地描述了DA在突出可塑性中的功能。本文将综述DA及其受体在中枢神经系统的分布及其作用,为今后的相关研究提供科学依据。

英文摘要：

Dopamine（DA）,as one of the most important catecholamine neurotransmitters in central nervous system（CNS）,plays an important role in regulating the motion,cognition,emotion,positive reinforcement,food intake,endocrine and many other functions of the brain.Dopamine is related to schizophrenia,Tourette’s syndrome,drug addiction,learning and memory deficits,attention deficit hyperactivity syndrome,etc.Numerous studies have demonstrated that dopamine plays a crucial role in regulating synaptic plasticity.The researchers adopted different receptor agonists and antagonists to study the functions of dopamine,especially after the five dopamine receptors were found,and they described the functions of dopamine more specifically in synaptic plasticity.This article summarizes the distribution and effect of dopamine and its receptors in the central nervous system,which provides the scientific basis for future research.