位置：成果数据库 > 期刊 > 期刊详情页
A Smart DNAzyme–MnO2 Nanosystem for Efficient Gene Silencing
  • ISSN号：1433-7851
  • 期刊名称：Angewandte Chemie International Edition
  • 时间：2015.4.13
  • 页码：4883-4887
  • 相关项目：化学生物传感的分析化学基础研究
作者： Huanhuan Fan, Zilong Zhao, Guobei Yan, Xiaobing Zhang|Chao Yang, Hongmin Meng, Zhuo Chen, Hui Liu, and Weihong Tan*|
同期刊论文项目
化学生物传感的分析化学基础研究
期刊论文 304
同项目期刊论文
Noncanonical Self-Assembly of Multifunctional DNA Nanoflowers for Biomedical Applications
Versatile DNAzyme-Based Amplified Biosensing Platforms for Nucleic Acid, Protein, and Enzyme Activit
Engineering and applications of DNA-grafted polymer materials
Using Aptamers for Cancer Biomarker Discovery
A simple and pH-independent and ultrasensitive fluorescent probe for the rapid detection of Hg2+
A Targeted, Self-Delivered, and Photocontrolled Molecular Beacon for mRNA Detection in Living Cells
Development of a highly robust solid phase microextraction fiber based on crosslinked methyl methacr
Sensitive Electrochemical Aptasensor by Coupling “Signal-on” and “Signal-off” Strategies
Simultaneous electrochemical detection of ascorbic acid, dopamine and uric acid based on nitrogen do
Sensitive electrochemical detection of hydroxyl radical based on MBs-DNA-AgNPs nanocomposite
A Controlled-Release Nanocarrier with Extracellular pH Value Driven Tumor Targeting and Translocatio
Recent Advances in Optical Imaging with Anisotropic Plasmonic Nanoparticles
A flexible trilineardecomposition algorithm for three-way calibration based on the trilinear compone
Noncovalent assembly of reduced graphene oxideand alkyl-grafted mesoporous silica: an effective drug
Targeted Intracellular Controlled Drug Delivery and Tumor Therapy through in Situ Forming Ag Nanogat
Localizableand Photoactivatable Fluorophore for Spatiotemporal Two-Photon Bioimaging
DNA-templated in situ growth of silver nanoparticles on mesoporous silica nanospheres for smart intr
Rapid andsimultaneous determination of five vinca alkaloids in catharanthus roseus andhuman serum us
A combination of positive dielectrophoresis driven on-line enrichment and aptamer-fluorescent silica
Redox-responsive degradable honeycomb manganese oxide nanostructures aseffective nanocarriers for in
Single-base mismatch discrimination by T7 exonuclease with target cyclic amplification detection
Ultrasensitive Detection of Single Nucleotide Polymorphism inHuman Mitochondrial DNA Utilizing Ion-M
Magnetic graphene oxide modified with choline chloride-based deep eutectic solvent for the solid-pha
Ultrasensitive Electrochemical Detection of Nucleic Acids Based on the Dual-Signaling Electrochemica
DNA “Nano-Claw”:Logic-Based Autonomous Cancer Targeting and Therapy
Enzymatic cleavage and mass amplification strategy for small molecule detection using aptamer-based
Cell-SELEX-based aptamer-conjugated nanomaterials for cancer diagnosis and therapy
Magnetic-graphene based molecularly imprinted polymer nanocomposite for the recognition of bovine he
Rationally designed molecular beacons for bioanalytical and biomedical applications
Using DNA Aptamer Probe for Immunostaining of Cancer Frozen Tissues
Poly(thymine)-Templated Copper Nanoparticles as a Fluorescent Indicator for Hydrogen Peroxide and Ox
Analysis of perfluorooctane sulfonate and perfluorooctanoic acid with a mixed-mode coating-based sol
Label-Free and Turn-on Aptamer Strategy for Cancer Cells Detection Based on a DNA−Silver N
Engineering a Cell-Surface Aptamer Circuit for Targeted and Amplified Photodynamic Cancer Therapy
A New Dual-Signalling Electrochemical Sensing Strategy Based on Competitive Host–Guest Int
Versatile Electrochemiluminescent Biosensor for Protein−Nucleic Acid Interaction Based on
Deep eutectic solvents as novel extraction media for protein partitioning？
Self-assembly synthesis of a hierarchical structure using hollow nitrogen-doped carbon spheres as sp
The prepartion of magnetic molecularly imprinted nanoparticles for the recognition of bovine hemoglo
Remote-Controlled Release of DNA in Living Cells via Simultaneous Light and Host–Guest Mediations
Development of spiropyran-based electrochemical sensor via simultaneous photochemical and target-act
Supercharged fluorescent protein as a versatile probe for homogenous DNA detection and methylation a
Intra-molecular G-quadruplex structure generated by DNA-templated click chemistry: “Turn-on” fluores
A novel mix-and-read fluorescent strategy for turn-on probing kinase activity based on aptameric pep
Two novel zeolitic imidazolate frameworks (ZIFs) as sorbents for solid-phase extraction (SPE) of pol
An aptamer-based quartz crystal microbalance biosensor for sensitive and selective detection of leuk
Enhanced nonenzymatic sensing of hydrogen peroxide released from living cells based on Fe3O4/self-re
The adenine DNA self-assembled of pH- and near-infrared-responsive gold nanorods vehicle for chemoth
Gold nanorod-seeded synthesis of Au@Ag/Au nanospheres with broad and intense near-infrared absorptio
Co-loading of coralyne and indocyanine green into adenine DNA-functionalized mesoporous silica nanop
Ligation–rolling circle amplification combined with γ-cyclodextrin mediated stemless molecular beaco
Amplified electrochemical detection of protein kinase activity based on gold nanoparticles/multi-wal
Remote-controlled drug release from graphene oxide-capped mesoporous silica to cancer cells by photo
Label-free activatable aptamer probe for colorimetric detection of cancer cells based on binding-tri
Visual and Portable Strategy for Copper(II) Detection Based on a Striplike Poly(Thymine)-Caged and M
dsDNA-specific fluorescent copper nanoparticles as a ‘‘green’’ nano-dye for polymerization-mediated
Target-catalyzed dynamic assembly-based pyrene excimer switching for enzyme-free nucleic acid amplif
Nanometer-sized manganese oxide-quenched fluorescent oligonucleotides: an effective sensing platform
Concatemeric dsDNA-Templated Copper Nanoparticles Strategy with Improved Sensitivity and Stability B
A Versatile Activatable Fluorescence Probing Platform for Cancer Cells in Vitro and in Vivo Based on
Aptamer-fluorescent silica nanoparticles bioconjugates based dual-color flow cytometry for specific
Inorganic fluorescent nanoprobes for cellular and subcellular imaging: status and challenges
Au@Ag/Au nanoparticles assembled with activatable aptamer probes as smart “nanodoctors” for image-gu
pH-responsive polymer/mesoporous silica nano-container through an acid cleavable linker for intracel
Cell Membrane-Anchored Biosensors for Real-Time Monitoring of the Cellular Microenvironment
Isothermal Nucleic Acid Amplification Strategy by Cyclic Enzymatic Repairing for Highly Sensitive Mi
Magnetic separation–enrichment-mediated signal amplification for a simple and sensitive fluorometric
Direct Imaging of Transmembrane Dynamics of Single Nanoparticles with Dark？eld Microscopy: Improved
High-Throughput Sul？de Sensing with Colorimetric Analysis of Single Au？Ag Core？Shell Nanoparticles
Color Di？erence Ampli？cation between Gold Nanoparticles in Colorimetric Analysis with Actively Contr
Direct image of single gold nanoparticle etching: sensitive detection of lead ions
Reversible Phase Transfer of Nanoparticles Based on Photoswitchable Host-Guest Chemistry
Facile Surface Functionalization of Hydrophobic Magnetic Nanoparticles
DNA “Nano-Claw”: Logic-Based Autonomous Cancer Targeting and Therapy
Molecular Engineering of a TBET-Based Two-Photon Fluorescent Probe for Ratiometric Imaging of Living
Activatable Fluorescence/MRI Bimodal Platform for Tumor Cell Imaging via MnO2 Nanosheet–Aptamer Nano
Automated Modular Synthesis of Aptamer–Drug Conjugates for Targeted Drug Delivery
Gold nanorod-photosensitizer conjugate with extracellular pH-driven tumor targeting ability for phot
Aptamer-conjugated nanomaterials for specific cancer cell recognition and targeted cancer therapy
A ratiometric electrochemical biosensor for sensitive detection of Hg2+ based on thymine-Hg2+-thymin
Nanomaterials as signal amplification elements in DNA-based electrochemical sensing
Simultaneous electrochemical determination of hydroquinone, catechol and resorcinol at nitrogen dope
Highly-selective electrochemical determination of catechol based on 3-aminophenylboronic acid-3,4,9,
PtRu nanoparticles supported on nitrogen-doped polyhedral mesoporous carbons as electrocatalyst for
Amplified impedimetric DNA sensor based on graphene oxide–phenylboronic acid for sensitive detection
Electrochemical determination of bleomycins based on dual-amplification of 4-mercaptophenyl boronic
A ratiometric electrochemical aptasensor for sensitive detection of protein based on aptamer-target-
A simple label-free electrochemical aptasensor for dopamine detection
基于硅量子点电子转移荧光淬灭的2,4,6-三硝基甲苯/2,4,6-三硝基苯酚检测新方法.
Intelligent layered nanoflare: “lab-on-a nanoparticle” for multiple DNA logic gate operations and ef
Design of functional guanidinium ionic liquid aqueous two-phase systems for the efficient purificati
Interference-free determination of Indole-3-Acetic acid in two real systems using second-order calib
Quantitative study of state switching in proteins using a single probe combined with trilinear decom
Magnetic solid-phase extraction of proteins based on hydroxy functional ionic liquid-modified magnet
Rhodamine-based fluorescent probe for direct bioimaging of lysosomel pH changes
An efficient ratiometric fluorescent excimer probe for hypochlorite based on a cofacial xanthene bri
An aggregated perylene-based broad-spectrum, efficient and label-free quencher for multiplexed fluor
Chemometrics-enhanced high performance liquid chromatography -diode array detection strategy for sim
Simultaneous determination of phenolic antioxidantsinedible vegetableoils by HPLC-FLD assisted withs
Alternating coupled two-unequal residual functions algorithm for second-order calibration.
Direct quantitative analysis of aromatic amino acids in human plasma by four-way calibration using i
三线性分解算法对液相色谱-质谱联用仪多样本测定数据分辨适用性的比较
Entropy beacon: a hairpin-free DNA amplification strategy forefficient detection of nucleic acids
Self-AssembledDNA Immunonanoflowers as Multivalent CpG Nanoagents
A FRET-based ratiometric two-photon fluorescent probe for dual-channelimaging of nitroxyl in living
A Cell-Targeted, Size-Photocontrollable, Nuclear-Uptake Nanodrug Delivery System for Drug-Resistant
A nove AgNP/DNA/TPdye Conjugate-basedTwo-photon Nanoprobe for GSH Imaging in Cell Apoptosis of Canc
STIP overexpression confers oncogenic potential tohuman non-small cell lung cancer cells by regulati
Self-assembledmultifunctional DNA nanoflowers for the circumvention of multidrug resistancein target
Ionization of Hydrophobic Colloidal Nanoparticles toForm a Unique Class of Nanozymes
Efficient Two-Photon Fluorescent Probe for NitroreductaseDetection and Hypoxia Imaging in Tumor Cell
Nucleic Acid Based Logical Systems
Functional DNA-Containing Nanomaterials: Cellular Applications in Biosensing, Imaging, and Targeted
Direct Visualization of Walking Motions of Photocontrolled Nanomachine on the DNA Nanostructure
A cascade reaction network mimicking the basic functional steps of adaptive immune response
Sensitive and Rapid Detection of Endogenous Hydrogen Sulfide Distributing in Different Mouse Viscera
Simultaneous determination of naphazoline and pyridoxine in eye drops using excitation–emission matr
Nuclease-resistant synthetic drug-DNA adducts: programmable drug-DNA conjugation for targeted antica
An efficient ratiometric fluorescent probe for tracking dynamic changes inlysosomal pH
Automatic and Integrated Micro-Enzyme Assay (AIμEA) Platform for Highly Sensitive Thrombin Analysis
DNA-mediated supercharged fluorescent protein/ Q1 Q2 graphene oxide interaction for label-free fluor
Solving signal instability to maintain the second-order advantage inthe resolution and determination
Chemometrics-assisted determination of amiloride and triamterene in biological fluids with overlappe
A Nonenzymatic Hairpin DNA Cascade Reaction Provides High Signal Gain of mRNA Imaging inside Live C
Through-Bond Energy Transfer-Based Ratiometric Two-Photon Probe for Fluorescent Imaging of Pd2+ Ions
A rhodamine-appended water-soluble conjugated polymer: anefficient ratiometric fluorescence sensing
Silver Nanoparticle Gated, Mesoporous Silica Coated Gold Nanorods (AuNR@MS@AgNPs): Low Premature Rel
Electrostatic nucleic acid nanoassembly enables hybridization chain reaction in living cells for ult
Nucleic acid amplification-based methods formicroRNA detection
Split aptamer mediated endonuclease amplification for small-molecule detection
Hemicyanine-based High Resolution Ratiometric near-Infrared Fluorescent Probe for Monitoring pH Chan
Iodide-Responsive Cu？Au Nanoparticle-Based Colorimetric Platform for Ultrasensitive Detection of Tar
Masking agent-free and channel-switch-mode simultaneous sensing of Fe3+ and Hg2+ using dual-excitati
Preparation of magnetic chitosan and graphene oxide-functional guanidinium ionic liquid composite fo
A ratiometric electrochemical biosensor for sensitive detection of Hg2+ based on thymine–Hg2+–thymin
A label-free electrochemical strategy for highly sensitive methyltransferase activity assays
PlatinumNanoparticles Encapsulated in Nitrogen-Doped Mesoporous Carbonsas Methanol-Tolerant Oxygen R
A new ratiometric electrochemical sensor for sensitive detection of bisphenol A based on poly-b cycl
双牺牲模板法制备一维管状Pt-Mn3O4-C复合物及其优越的甲醇电催化氧化性能
Nucleic acid-mimicking coordination polymer for label-free fluorescent activity assay of histone ace
A universal platform for building molecular logic circuits based on a reconfigurable three dimension
Fast quantitative analysis of four tyrosine kinase inhibitors in different human plasma samples usin
DNA Aptamer Selected against Pancreatic Ductal Adenocarcinoma for in vivo Imaging and Clinical Tissu
Studyof the Function of G-Rich Aptamers Selected for Lung Adenocarcinoma
Programmed packaging of mesoporous silica nanocarriers for matrixmetalloprotease 2-triggered tumor t
A highly sensitive electrochemiluminescence assay for protein kinase based on double-quenching of gr
Glutathione-Mediated Degradation of Surface-Capped MnO 2 for Drug Release from Mesoporous Silica Nan
Adenosine-5-Triphosphate Aptamer Containing Triple-Helix DNA Capped Mesoporous Silica Nanoparticles
Optical analysis of biological hydrogen sulphide:an overview of recent advancements
Fluorescent Gold Nanodots Based Sensor Array for Proteins Discrimination
Phosphorylation-Mediated Assembly of a Semisynthetic Fluorescent Protein for Label-Free Detection of
Multi-targeted interference-free determination of ten β-blockers in human urine and plasma samples b
Lateral epitaxial growth of two-dimensional layered semiconductor heterojunctions
Nucleic Acid Aptamers for Living Cell Analysis
A pH-responsive polymer/mesoporous silica nano-container linked through an acid cleavable linker for
Building a Multifunctional Aptamer-Based DNA Nanoassembly for Targeted Cancer Therapy
Targeted Bioimaging and Photodynamic Therapy Nanoplatform Using an Aptamer-Guided G-Quadruplex DNA C
三维荧光二阶校正同时测定人体液中伊立替康及其代谢物7-乙基-10-羟基喜树碱的含量
Annexin-V modified QCM sensor for the label-free and sensitive detection of early stage apoptosis
A new strategy based on cholesterol-functionalized iron oxide magnetic nanoparticles for determinati
A superquenched DNAzyme-perylene complex: a convenient, universal and low-background strategy for fl
DNA Micelle Flares for Intracellular mRNA Imaging and Gene Therapy
DNAzyme-Based Probes for Telomerase Detection in Early-Stage Cancer Diagnosis
Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer
Building Fluorescent DNA Nanodevices on Target Living Cell Surfaces
Multicolor Fluorescent Biosensor for Multiplexed Detection of DNA
DNA Nanoflowers for Multiplexed Cellular Imaging and Traceable Targeted Drug Delivery
A highly sensitive and reductant-resistant fluorescent probe for nitroxyl in aqueous solution and se
A rhodamine-appended water-soluble conjugated polymer: an efficient ratiometric fluorescence sensing
Programmable and Multiparameter DNA-Based Logic Platform For Cancer Recognition and Targeted Therapy
Single Nanoparticle to 3D Supercage: Framing for an Artificial Enzyme System
Preparation and biomedical applications of programmable and multifunctional DNA nanoflowers
Alabel-freeDNAzyme fluorescencebiosensorforamplified detection of Pb2+-based oncleavage-induced G-qu
Selective Colorimetric Detection of Hydrogen Sulfide Based on Primary Amine-Active Ester Cross-Linki
Quantitative investigation of the dynamic interaction of human serum albumin with procaine using a m
Screening of DNA Aptamers against Myoglobin Using a Positive and Negative Selection Units Integrated
Aptamer/target binding-induced triple helix forming for signal-on electrochemica lbiosensing
Magnetic multiwall carbon nanotubes modified with dual hydroxy functional ionic liquid for the solid
DNA Aptamer-Mediated Cell Targeting
Selective Tracking of Lysosomal Cu2+ Ions Using Simultaneous Target- and Location-Activated Fluoresc
Ultrasensitive and Highly Selective Detection of Bioaccumulation of Methyl-Mercury in Fish Samples v
DNA-templated in situ growth of AgNPs on SWNTs: a new approach for highly sensitive SERS assay of mi
Self-assemblyof DNA Nanohydrogels with Controllable Size and Stimuli-Responsive Property for Targete
Evolution of Functional Six-Nucleotide DNA
Multiple Functional Nanoprobe for Contrast-Enhanced Bimodal Cellular Imaging and Targeted Therapy
DLISA:A DNAzyme-Based ELISA for Protein Enzyme-Free Immunoassay of Multiple Analytes
核酸适配体功能化近红外量子点结合流式细胞术快速检测白血病细胞
基于硅量子点电子转移荧光淬灭的2,4,6-三硝基甲苯/2,4,6-三硝基苯酚检测新方法
三线性分解方法用于光谱数据中背景漂移的扣除
“金标银染”放大技术的羟基自由基灵敏检测
Pt纳米颗粒在聚二甲基二烯丙基氯化铵功能化碳纳米管上的自发沉积及其对甲醇的电催化氧化性能（英文）
核酸适配体靶向药物的“导航仪”研究
Self-assembled multifunctional DNA nanoflowers for the circumvention of multidrug resistance in targeted anticancer drug delivery
Fabrication of ultrathin Zn（OH）2 nanosheets as drug carriers
Background-free three-dimensional selective imaging of anisotropic plasmonic nanoparticles