欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
CD4＋T细胞各亚群在类风湿关节炎（RA）的发生发展过程中发挥不同的作用。其中，辅助性T细胞1（Thl）／Th2细胞、Thl7／调节性T细胞（Treg）细胞比例的失衡及细胞因子白细胞介素-1（IL-1）、IL-2、干扰素-γ（IFN-γ）、肿瘤坏死因子-α（TNF-α）等产生的免疫损害，是导致RA慢性炎症的关键因素。TNF-α作为一种重要的促炎细胞因子在RA致病过程中起到了重要作用。TNF-α有两个受体，TNF受体1（TNFreceptor1，TNFRl）在大多数细胞上表达，而TNFR2仅在T细胞等免疫细胞上表达，调节T细胞的存活、活化和增殖。反之，T细胞对TNF-α信号通路也有影响。该文就RA的发病机制中TNF-α及其信号通路和CD4＋T细胞各亚群功能的关系加以综述，为RA的防治提供新的思路。
英文摘要：
CD4＋ T cell subsets play different roles in the patho- genesis of rheumatoid arthritis （RA）. The helper T （Thl）/Th2 and Thl7/regulatory T cells （Treg） imbalance and pro-inflamma- tory cytokines, such as interleukin-1 （ IL-1 ）, IL-2, interferon-γ （IFN-γ） and tumor necrosis factor-α（TNF-α）, are the key fac- tors in the chronic inflammation of RA. TNF-α interacts with two different receptors, designated TNF receptor 1 （TNFR1） and TNFR2, which are expressed in different cells and tissues. TN-FR1 is expressed in most cells. However, TNFR2 is only ex- pressed in T cells and other immune cells which regulate the sur- vival, activation and proliferation of T-lymphocytes. This review summarizes the relationship between TNF-α signaling pathway and the function of CD4＋ T cell subsets in the pathogenesis of RA in an attempt to provide new ideas for the treatment of RA.
同期刊论文项目
同项目期刊论文
Involvement of the prostaglandin E receptor EP2 in paeoniflorin-induced human hepatoma cell apoptosi
Selective alpha(1B)- and alpha(1D)-adrenoceptor antagonists suppress noradrenaline-induced activatio
IL-21 acts as a promising therapeutic target in systemic lupus erythematosus by regulating plasma ce
Effect of bone marrow-derived CD11bF4/80 immature dendritic cells on the balance between pro-inflamm
4-Amino-2-trifluoromethyl-phenyl retinate inhibits the migration of BGC-823 human gastric cancer cel
Ginsenoside compound K suppresses the abnormal activation of T lymphocytes in mice with collagen-ind
Ginsenoside metabolite compound K attenuates inflammatory responses of adjuvant-induced arthritis ra
Ginsenoside Metabolite Compound K Alleviates Adjuvant-Induced Arthritis by Suppressing T Cell Activa
Similar survival, but better quality of life after myeloablative transplantation using unrelated cor
ACETYLSALICYLIC ACID ENHANCES THE ANTI-INFLAMMATORY EFFECT OF FLUOXETINE THROUGH INHIBITION OF NF-ka
Dendritic cells with an increased PD-L1 by TGF-beta induce T cell anergy for the cytotoxicity of hep
The renoprotective effects of berberine via the EP4-G alpha s-cAMP signaling pathway in different st
Bone marrow CD11b(+)F4/80(+) dendritic cells ameliorate collagen-induced arthritis through modulatin
Etanercept attenuates collagen- induced arthritis by modulating the association between BAFFR expres
Etanercept attenuates collagen-induced arthritis by modulating the association between BAFFR express
Hedgehog signaling pathway mediates invasion and metastasis of hepatocellular carcinoma via ERK path
Prednisone treatment inhibits the differentiation of B lymphocytes into plasma cells in MRL/MpSlac-l
期刊信息
位置：