目的对1986年至2010年我国0~7岁儿童单纯性肥胖流行病学的临床资料进行Meta分析,描述肥胖发生率历年变化情况。方法以“儿童”、“超重”和“单纯性肥胖”为中文关键词,“child”、“over-weight”和“simple obesity”为英文关键词,在中文科技期刊数据库、中国生物医学文献数据库、中国期刊全文数据库、万方数据资源系统和PubMed、CochraneLibrary上检索1980年1月1日至2012年7月31日中英文文献,按评分标准纳入标准筛选文献,利用Stata10.0软件对纳入文献进行Meta分析,通过Begg’s检验绘制漏斗图,评估各文献的发表偏倚,同时进行异质性检验,采用适当模型计算患病率和95%CI,比较男童和女童的患病率。结果共纳入14篇文献,提取0—7岁儿童样本总量126310例,男66558例,女59752例,儿童单纯性肥胖发病率为4.30%,95%CI:3.30%~5.40%,男童肥胖发病率为4.80%,95%CI:3.60%~6.00%,女童肥胖发病率为3.70%,95%CI:2.80%~4.60%;男女肥胖发病率在1986年至1995年差异无统计学意义(P〉0.05),在1996年至2010年差异有统计学意义(P〈0.05),且差异逐渐增大。结论1986年至2010年儿童单纯性肥胖发病率持续上升,男女对比差异也逐渐增大,亟须引起国家重视,出台政策干预和预防儿童单纯性肥胖的发生发展。
Objective To describe the change of obesity incidence over the years by evaluating simple obesity children aged 0 - 7 years old during 1986 to 2010 in China. Methyls Relevant articles were searched for in PubMed, Cochrane Library, Chinese Science Citation Database, CBM, CNKI and Wanfang Database using the key words of "child" ," overweight" and "simple obesity" in English and Chinese articles between Jan. 1,1980 and Jul. 31,2012. A criterion for inclusion was established based on valid criteria for diagnostic research. The eligible studies were collected and analyzed using Stata 10.0. Publication bias was tested by Begg's funnel plot. The heterogeneity test was performed at the same time. The appropriate models was used to calculate prevalence rate and 95% CI and study gender effect among children. Results Fourteen articles were included with a total of 126 310 children(66 558 boys and 59 752 girls ). The rate of child obesity was 4.30 % , 95 % CI: 3.30 % - 5.40 % ; boys : 4.80 %, 95 % CI: 3.60 % - 6.00 % ; girls : 3.70% ,95% CI:2.80% -4. 60%. There was no difference between boys and girls in obesity incidence from 1986 to 1995(P 〉0.05) ,while differences appeared from 1996 to 2010(P 〈0.05). Conclusions In the 1986 to 2010 period both child obesity incidence and differences between boys and girls continued to increase. The government shall pay attention to such a situation at once and introduce polices to prevent the continuous development of the children simple obesity.