中文摘要：

多年来人们认为细胞死亡方式主要包括坏死和凋亡。坏死是不受特定调控的被动死亡方式，表现为细胞器肿胀，细胞膜破裂，内容物渗出，有炎症反应[1]，而凋亡则是由细胞内胱天蛋白酶（caspase）调控的一种主动死亡方式，因caspase激活导致细胞内底物裂解，破坏胞膜囊泡形成凋亡小体，死亡过程中无内容物渗出，不引起炎症反应[2]。

英文摘要：

Necroptosis, or programmed cell death, is a type of cell death with a controllable death signaling pathway and the morphological features similar to necrosis. It is mainly mediated by death receptors or pathogen pattern re- cognition receptors. Among them, tumor necrosis factor receptor 1 （ TNFR1 ） -mediated necroptosis is the most well-studied one. Receptor-interacting protein kinase 1 （ RIPK1 ） and receptor-interacting protein kinase 3 （ RIPK3 ） are the 2 key kina- ses involved in the formation of complex I ＆ II and necrosome in the process of necroptosis. Phosphoglycerate mutase 5 （ PGAM5 ） , a member of phosphoglycerate mutase gene family, lacks PGAM activity and possesses the phosphatase activi- ty. PGAM5 is anchored in the mitochondrial membrane and is also called mitochondrial phosphoglycerate mutase 5. It has been shown that PGAM5 involves in the formation of necrosome during neeroptosis and it is able to accelerate the fission of mitochondria by dephosphorylation of dynamin-related protein 1 （ DRP1 ）, thus promoting cell necroptosis.