中文摘要：

以卤虫致死活性和HPLC-DAD图谱为指导,充分利用正相、反相色谱技术,对采自南海北部3536 m深的海底沉积放线菌Streptomyces sp.SCSIO 5604的活性次级代谢产物进行了研究,从中分离到一个吲哚内酰胺类化合物,经HR-ESI-MS、1H NMR、13C NMR波谱分析,确定其为lyngbyatoxin A。

英文摘要：

The strain SCSIO 5604 was identified to be Streptomyces sp. by 16S rRNA gene sequence,which was isolated from a sediment sample collected in South China Sea at E 120° 0.250＇ and N 20° 22. 971＇ at 3536 m depth. Guided by brine shrimp lethality and HPLC-DAD, chemical analysis of the crude extract of the fermentation culture,led to the isola- tion of an indolelactam compound, namely lyngbyatoxin A. The structure of lyngbyatoxin A was identified based on the HR-ESI-MS, I H NMR, 13C NMR spectra and comparing with literature data.