中文摘要：

目的对血管紧张素转换酶抑制剂（ACEI）和血管紧张素受体拮抗剂（ARB）治疗原发性高血压（EH）患者蛋白尿的疗效进行Meta分析。方法计算机检索2001～2011年PubMed数据库、Elsevier数据库、中国期刊全文数据库、中国生物医学文献数据库,纳入比较ACEI和ARB治疗EH患者尿蛋白的随机对照研究,包括24 h尿总蛋白（24hUTP）、24 h尿白蛋白（24hUAlb）、尿微量白蛋白（MA）,利用RevMan5.0软件统计分析。结果共纳入符合标准文献19篇。其中13篇文献报道了24hUTP,7篇文献报道了24hUAlb,4篇文献报道了MA。在降低EH患者尿蛋白方面,ACEI和ARB比较差异有统计学意义（P〈0.05）。结论 ARB降低EH患者蛋白尿的疗效优于ACEI。

英文摘要：

Objective To compare the efficacy of angiotensin-converting enzyme inhibitor（ACEI） and angiotensin receptor blocker（ARB） in the treatment of proteinuria in essential hypertension（EH）. Methods Databases were searched,including Pubmed, Elsevier, CNKI and CBM during 2001 to 2011. Trials about ACEI and ARB for proteinuria of EH, including 24 hours urinary total protein excretion （24hUTP） ,24 hours albumin excretion rate （24hUAlb） and micrealbuminuria （ MA）, were included. Rev Man 5.0 software was used for meta-analysis. Results A total of 19 articles were included, of which 13 articles reported 24hUTP, and ？ articles reported 24hUAlb, and 4 articles reported MA. ACEI therapy and ARB had significant differ- ence（ P 〈 0.05 ） in lowering proteinuria of EH patientsly. Conclusion ARB is more efficient than ACEI to reduce the ureteinuria of EH natients.