中文摘要：

设计并合成了一种新型自组装多肽纳米荧光探针.在合成方法上使用了新型的生物兼容性的CBT-Cys点击反应实现了RGD肽的环化.该探针可通过RGD序列靶向肿瘤细胞αvβ3整合素受体,促进细胞的摄取;同时可与细胞内弗林酶作用导致荧光的“关-开”,达到对肿瘤细胞的靶向荧光成像功能.

英文摘要：

A new self-assembled nano fluorescence probe was designed and synthesized. The new biocompatible CBT-Cys click reaction was used to cyclize RGD peptide in synthesis method. Using ROD peptide sequence, this probe can targetav133 integrin of cancer cells and react with furin enzyme in cells, resulting in fluorescence＂Off-On＂. Thus it achieves the ability to target tumor cells for fluorescence imaging.