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Iriomoteolide-1b中C（13）-C（23）片段的立体选择性合成
  • ISSN号：0253-2786
  • 期刊名称：《有机化学》
  • 时间：0
  • 分类：O623.521[理学—有机化学;理学—化学]
  • 作者机构：[1]兰州大学化学系功能有机分子化学国家重点实验室,兰州730000
  • 相关基金：国家自然科学基金（Nos.20872054,20732002）资助项目
作者： 杨震[1], 靖鹏[1], 厍学功[1]
关键词： Iriomoteolide-1b, 立体选择性合成, 不对称Evans-aldol反应, Julia-Kocienski成烯反应, iriomoteolide-1b, stereoselective synthesis, asymmetric aldol reaction, Julia-Kocienski olefination
中文摘要：

采用已知文献报道的化合物为起始原料,以不对称Evans-aldol反应和Julia-Kocienski成烯反应为关键步骤,对大环内酯化合物Iriomoteolide-1b的C（13）-C（23）片段结构进行了合成研究.全文使用普通而廉价的原材料或者试剂,采用常规的容易操作的反应条件,实验成本比较低,并且以13步13%的产率得到了C（13）-C（23）片段结构.

英文摘要：

A stereoselective synthesis of C（13）-C（23） subunit of iriomoteolide-1b has been achieved in 13% yield over 13 steps from the known diol,exploiting the asymmetric aldol reaction and the Julia-Kocienski olefination as the key steps.In order to reduce the cost of the synthesis we adopted usual reactions and used inexpensive reagents through the synthesis strategy.

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大环内酯类天然产物Iriomotolide的全合成及其构效关系研究
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涉及氮原子参与的不对称反应与合成策略研究及其在天然生物碱不对称全合成中的应用
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期刊信息
  • 《有机化学》
  • 中国科技核心期刊
  • 主管单位:
  • 主办单位:中国化学会 中国科学院上海有机化学研究所
  • 主编：陈庆云
  • 地址：上海市枫林路354号
  • 邮编：200032
  • 邮箱：bianji@mail.sioc.ac.cn
  • 电话：021-54925244
  • 国际标准刊号：ISSN：0253-2786
  • 国内统一刊号：ISSN：31-1321/O6
  • 邮发代号:4-285
  • 获奖情况:
  • 中国期刊方阵“双效”期刊
  • 国内外数据库收录:
  • 俄罗斯文摘杂志,美国化学文摘（网络版）,荷兰文摘与引文数据库,美国科学引文索引（扩展库）,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,中国北大核心期刊（2000版）
  • 被引量:14408