中文摘要：

精力新陈代谢是显著地，在许多人的癌症的 reprogrammed，和这些改变授与许多优点到癌症房间包括生合成的提升，快速的增长的 ATP 产生， detoxification 和支持。戊糖磷酸盐小径(PPP ) 是为葡萄糖分解代谢的一条主要小径。PPP 指导葡萄糖流动到它的氧化分支并且生产菸碱腺嘌 dinucleotide 磷酸盐(NADPH ) 的一种减少的形式，在 anabolism 的过程的必要 reductant。PPP 在由为细胞内部的反应的氧种类，减少的生合成和核糖生物的续生说的 detoxification 与不仅 ribose-5-phosphate 而且 NADPH 供应细胞调整癌症细胞生长起一个关键作用，变得清楚。因此， PPP 的改变直接作出贡献到房间增长，幸存和老朽。而且，最近的研究证明了 PPP 被众多的因素 oncogenically 或新陈代谢地调整，包括肿瘤 suppressors， oncoproteins 和细胞内部的代谢物。PPP 流动的 Dysregulation 戏剧性地影响癌症生长和幸存。因此，一更好 PPP 怎么是在癌症位于在 glycolysis 和 PPP 流动之间的平衡下面的 reprogrammed 和机制理解将在开发指向这条小径的治疗学的策略是珍贵的。

英文摘要：

Energy metabolism is significantly reprogrammed in many human cancers, and these alterations confer many advantages to cancer cells, including the pro- motion of biosynthesis, ATP generation, detoxification and support of rapid proliferation. The pentose phos- phate pathway （PPP） is a major pathway for glucose catabolism. The PPP directs glucose flux to its oxi- dative branch and produces a reduced form of nico- tinamide adenine dinucleotide phosphate （NADPH）, an essential reductant in anabolic processes. It has become clear that the PPP plays a critical role in regulating cancer cell growth by supplying cells with not only ribose-5-phosphate but also NADPH for detoxification of intracellular reactive oxygen species, reductive biosynthesis and ribose biogenesis. Thus, alteration of the PPP contributes directly to cell pro- liferation, survival and senescence. Furthermore, recent studies have shown that the PPP is regulated oncogenically and/or metabolically by numerous fac- tors, including tumor suppressors, oncoproteins and intracellular metabolites. Dysregulation of PPP flux dramatically impacts cancer growth and survival. Therefore, a better understanding of how the PPP is reprogrammed and the mechanism underlying the balance between glycolysis and PPP flux in cancer will be valuable in developing therapeutic strategies targeting this pathway.