中文摘要：

阿尔茨海默病（Alzheimer’s disease，AD）是一种与年龄相关的进行性神经系统变性疾病，致残率高，且起病隐蔽、病程呈不可逆发展。因此，筛选并发现AD新的敏感和特异的生物标志物，尤其AD早期标志物，对提高AD患者生存率和生存质量意义重大，己成为AD早期诊断与治疗的关键。本文仅对AD蛋白生物标志物的研究现状综述如下。

英文摘要：

Alzheimer＇s disease is a kind of neuron degenerative disorders which is characterized by progressive and irreversible loss of brain neurons, cognitive disorders, memory impairment are the main clinical features. The aging of the population gives a sharp rise in the number of AD patients. Therefore, screening and finding new sensitive and specific biomarkers, especially early AD biomarkers, is very important for improving the AD patients survival rate and quality of life, it has become the key of early diagnosis and treatment of AD. In this paper, the progress of the protein biomarkers forAD is reviewed.