中文摘要：

基因因素在疾病的发生发展中扮演着重要的角色，遗传关联性研究是基因与人类复杂疾病的重要研究方法之一。但在关联分析领域存在一种“赢者诅咒”现象，此外，由于单个基因效应对大多数疾病来说均较小，因此，需要大样本研究来探索其真实效应。本文主要简要介绍遗传关联性研究及其Meta分析的方法以及报告规范。

英文摘要：

Gene plays an important role in the development and progression of diseases. The geneticassociation study is one of the vital approaches in the field of association between gene and complex diseases inhuman. However, a “winner’s curse” phenomenon is existed in the field of association study. In addition, theeffect of each gene is relatively mild, therefore, large size sample studies are warranted to detect the true gene effect.The aim of this paper is to give a brief introduction of methods and reporting guideline of the genetic associationstudies and corresponding Meta-analyses.