中文摘要：

阻塞性睡眠呼吸暂停综合征（obstructive sleep apnea syndrome，OSAS）是由于睡眠时上气道阻塞，呼吸时上气道阻力增加，使呼吸变浅变慢或暂停，继而引起反复发作的低氧和高碳酸血症，是多种心血管疾病如高血压、心律失常、心肌缺血和心衰以及心脏猝死的重要危险因素¨引。它不仅可以引起急性血流动力学改变，长期效应还可引起慢性血流动力学改变及心脏结构和功能变化。大量文献显示间歇性低氧可引起左心功能损伤。

英文摘要：

Intermittent hypoxia （IH） is a direct consequence of obstructive sleep apnea syndrome （ OSAS）, which results in left ventricular dysfunction, remodeling and myocardial cell injury. Understanding the mechanisms of 0SAS is important for us to prevent and treat the cardiovascular complications in the clinical practices. We summarize the effects of IH on left ventricular function, and analyze the mechanisms at the cellular and molecular levels, including oxidative stress, ion exchangers and inflammation. In addition, the effects of endothelin-1 and hypercapnia on IH-induced cardiac iniury are discussed.