中文摘要：

目的：通过实验研究证实气阴两虚证人群更易发生心血管事件,为临床气阴两虚证的合理干预提供参考依据。方法：ICR小鼠按随机数字表法分为空白对照组、异丙肾上腺素组、慢性间歇性缺氧组及慢性间歇性缺氧复合异丙肾上腺素组,测定各组小鼠心电图、超声心动图、血清CK-MB、hs-CRP含量,观察小鼠心脏组织病理变化。结果：与空白对照组比较,各模型组小鼠均出现心脏形态或功能异常,表现为心肌缺血、心肌耗氧量增加、心肌细胞空泡化和心肌酶升高,其中复合模型组损伤最为严重,与异丙肾上腺素组比较差异有统计学意义。结论：模拟气阴两虚证的慢性间歇性缺氧小鼠在给予异丙肾上腺素后,其心肌形态及功能损伤较单纯给予异丙肾上腺素小鼠更为严重,提示气阴两虚证人群在心肌耗氧量增加时有可能更易发生心血管事件,为临床气阴两虚证的合理有效干预提供了实验依据。

英文摘要：

Objective： To confirm the tendency of those people with Deficiency of both qi and yin syndrome（ DQYS）suffering from cardiovascular events by experimental research,and to provide a reference for rational management with DQYS people. Methods： Male ICR mice were randomly divided into the control group,Isoprinosine（ ISO） group,chronic intermittent hypoxia（ CIH） group,and the group of CIH combined with ISO（ CIH ＋ ISO）. Then electrocardiogram and ultrasonic cardiogram were both adopted to examine the alteration of T wave and ejection fraction（ EF）. Serum contents of CK-MB and hs-CRP were both determined by ELISA,and the cardiac pathological changes were observed by HE stain.Results Compared with the control group,mice in model group presented abnormal cardiac morphology or function,manifested as myocardial ischemia,increased myocardial oxygen consumption and myocardial cell vacuolization,as well as myocardial enzyme elevation. Among the three model groups,especially the mice in CIH ＋ ISO group showed the most serious injury（ P 〈 0. 05,compared with the ISO group）. Conclusion： Mice exposed to CIH condition could simulate the main clinical features of DQYS,and injection of ISO could induce the CIH model mice to present more serious cardiac damage compared with the ISO model mice. The results showed that people with DQYS are inclined to suffer from cardiovascular events,such as angina,myocardial infarction,etc. The present study also provided a rational management proposal for those susceptible people with DQYS.