中文摘要：

目的：观察海参冻干粉治疗更年期综合征肾阳虚证的临床疗效，并观察其对患者性激素水平的影响。方法选择30例更年期综合征肾阳虚证患者，观察并分析患者海参冻干粉治疗前后Kupperman症状评分和临床疗效，并分别测定患者治疗前后雌二醇（E2）、促卵泡生成激素（FSH）和促黄体生成激素（LH），比较其治疗前后的变化情况。结果海参冻干粉治疗后与治疗前相比，患者临床症状明显改善，临床总有效率为90％，Kupperman评分差异有统计学意义（P＜0．01）；海参冻干粉治疗后患者血清FSH、LH水平较治疗前下降，血清E2水平较治疗前升高，差异有统计学意义（P＜0．05）。结论海参冻干粉对更年期综合征肾阳虚证具有较好的治疗作用，对患者性激素水平有调节作用。

英文摘要：

Objective To observe the effect of freeze-dried sea cucumber powder in the treatment of patients with kidney-yang deficiency of perimenopause syndrome ,and to observe its effect on the levels of gonadal hormone . Methods 30 patients with kidney-yang deficiency of perimenopause syndrome were selected ,the changes of the Kup-perman score,the clinical effect and the levels of serum E2,FSH and LH before and after treatment were observed. Results After treatment,the clinical symptoms were significantly improved and the total effective rate was 90%.The improvement of Kupperman scores had significant difference （P〈0.01）.The serum level of E2 was increased signifi-cantly after treatment （P〈0.05）,while the serum levels of FSH and LH were decreased significantly （P〈0.05）. Conclusion Freeze-dried sea cucumber powder in the treatment of patients with kidney-yang deficiency of perimeno-pause syndrome has preferable clinical effects and can modify gonadal hormone levels .