CuCr bulk alloy was produced by mechanical alloying and explosive compaction technology. Four kinds of milling time were used to analyze the function and influence on mechanical alloying. The samples were characterized by X-ray diffraction and optical microscope, and the density and hardness of the four samples were detected. The results show that the CuCr grain size is decreased with the milling time increasing, and nano-crystalline is observed in both Cu and Cr phase after 20 h milling. The density and hardness of samples are also increased with the increase of the milling time, so that the sample relative density reaches 96.6% and hardness reaches HV 217. The results indicate that high quality of CuCr bulk alloy can be manufactured using explosive compaction method when mechanical alloying and explosive compaction process parameters are reasonably selected.