中文摘要：

糖代谢是癌症的一个典型特征，研究显示SMP30（senescence marker protein 30）是一种肝癌相关抗原，与脂代谢关系密切，为了探讨SMP30与糖代谢的变化是否相关，我们构建了稳定转染SMP30的人SK-HEP1肝癌细胞株。通过迁移实验、侵袭实验和CCK8实验对比检测了过表达SMP30组与对照组肝癌细胞的迁移、侵袭、增殖的情况；同时还检测了细胞的葡萄糖吸收、乳酸排出的情况。结果显示，与对照组相比，SMP30对SK-HEP1肝癌细胞株的迁移、侵袭有明显的抑制作用（p〈0．01）；对细胞的增殖作用不明显（p〉0．05）。过表达SMP30对肝癌细胞的葡萄糖吸收和乳酸排出作用不显著（p〉0．05）。SMP30对肝癌细胞SK-HEP1的迁移、侵袭有一定的抑制作用，但这种作用与糖代谢关系不明显。

英文摘要：

Glucose metabolism is a typical feature of cancer. Studies have shown that SMP30 （senescence marker protein 30） is a hepatocellular carcinoma-associated antigen, which is closely related to lipid metabolism. To investigate whether SMP30 was related to the change of glucose metabolism, we constructed a stable SK-HEP1 hepatocellular carcinoma cell line transfected with SMP30, and detected the migration, invasion and proliferation of the hepatocellular carcinoma cells in SMP30 overexpressing group and control group by migration experiment, invasion experiment and CCK8 test. At the same time, the glucose uptake and lactate excretion of cells were detected. The results showed that SMP30 had a significant inhibitory effect on the migration and the invasion of SK-HEP 1 liver cancer cell lines （p〈0.01） compared with the control group, and the proliferation effect on the cell was not obvious （p〉0.05）. Overexpression of SMP30 had no significant effect on the glucose uptake and lactate excretion （p〉0.05） ofhepatocellular carcinoma cells. SMP30 had certain inhibitory effect on the migration and invasion of the SK-HEP1, but the relationship between this effect and glucose metabolism was not obvious.