中文摘要：

晚期血友病关节炎患者往往因严重的关节功能障碍而影响日常生活。凝血因子的问世使人工关节置换术治疗重度血友病性关节炎变为可能。血友病性关节炎较多累及膝、髋关节,与全膝关节置换术相比,全髋关节置换术的文献报道相对较少,缺乏公认的治疗指南。因此,本文总结了全髋关节置换术治疗血友病性髋关节炎的相关文献,对其发病机制、凝血因子替代疗法、手术准备、术中及术后注意事项、术后血栓及凝血因子抗体形成的处理方法进行系统综述。本文旨在为应用全髋关节置换术治疗血友病性髋关节炎的围手术期的处理提供参考。

英文摘要：

The advanced stage haemophilic arthropathy is mostly characterized by poor function of multiple joints,resulting in a poor quality of life. However,haemophilic arthropathy can now be effectively treated by the arthroplasty combining coagulation factors. Haemophilic arthropathy of the hip joint is less common than that of knee,there are less reports and no commonly accepted management guidelines. This paper reviewed the current therapeutic progression of total hip arthroplasty in haemophilic arthropathy,summarizing the pathogenesis, coagulation factors replacement treatment, perioperative management,surgical techniques,thromboembolic prophylaxis and management for the antibodies of coagulation factors.The authors hope that this article could be helpful for the perioperative management of total hip arthroplasty in haemophilic arthropathy.