中文摘要：

建立兔下颌骨缺损模型,观察纳米β-TCP/明胶/鹿茸多肽复合材料的修复效果,以期来研究复合材料的成骨效能。取80只实验用新西兰大白兔进行同期颌骨缺损造模,随机均分为材料1组（鹿茸多肽含量5 mg/g）、材料2组（鹿茸多肽含量20 mg/g）、材料3组（不合鹿茸多肽）及对照组（无材料组）。分别在2、4、8、12周对造模部位取材,每组每次取5只,做组织学及扫描电镜（SEM）分析。材料植入后4周即可见到明显的新骨生成,并且材料1组明显优于其他3组。材料3组也有少量的新骨生成,对照组新骨生成缓慢,缺损区内被脂肪组织、血管以及纤维结缔组织所填埋,有少量的不连续的骨小梁生成。术后临床观察并无其他并发症,组织学观察骨缺损区内未见明显组织坏死和炎症细胞浸润。纳米β-TCP/明胶/鹿茸多肽复合材料对兔下颌骨缺损具有良好的修复效果。

英文摘要：

This study was designed to evaluate the effect of Nano β-TCP/Gelatin/Velvet Antler Polypeptide（Nano β-TCP /Gelatin/VAP） bone graft substitutes on the reparative capacity in rabbit mandible defect.In this study,the clinical result,macrography observation and histological evaluation are presented on 80 consecutively treated rabbits. They were divided into four groups：material group 1（containing 5 mg/g of VAP）,material group 2（containing 20 mg/g of VAP）,material group 3（no VAP） and control group（blank）.Samples were harvested according to the schedule（four groups）：five animnls after 2,4,8 and 12 weeks respectively,and the implants were harvested for macrography observation,histological and SEM analysis.These suggest that the Nano β-TCP/Gelatin in combination with VAP provide a viable therapeutic alternative for implant placement.The Nano β-TCP/Gelatin/VAP materials may promote bone formation in rabbit mandible area.And the groupl resulted in a higher quality and quantity of new bone formation was than the other three groups in 4 weeks.The defect of control group was filled by the adipose tissue, blood vessels,fibrous connective tissue and irregular bone trabeculae which is not continuous.Both groups were no obvious necrosis and inflammatory cell infiltration in the region of defect.The Nano β-TCP/Gelatin/Velvet Antler Polypeptide（Nano β-TCP/Gelatin/VAP） bone graft substitutes possesses the manifest reparative capacity in rabbit mandible defect.