中文摘要：

目的利用功能磁共振成像技术研究肝硬化病人静息态脑网络是否存在异常改变。方法14例肝硬化病人和14例正常对照者参加了本研究。汉字Stroop任务作为靶刺激任务，对照任务为“十”。采用组块式设计，回波平面成像血氧水平依赖的fMRI序列采集原始数据，采用SPM99软件中的组分析方法（对照状态减去任务状态）进行统计学处理。结果肝硬化病人的静息态脑网络不同于正常对照组，执行不一致的认字任务时，扣带回后部皮层、楔前叶未见激活，而执行颜色命名任务时，静息态的默认脑功能区激活明显增加。结论扣带回后部皮层和楔前叶是肝硬化病人脑损害的敏感部位，但不是特异的生物学标记。

英文摘要：

Objective To explore resting state network in patients with hepatic cirrhosis using functional magnetic resonance imaging （fMRI）. Methods 14 patients with hepatic cirrhosis and 14 healthy volunteers were included in this study. Modified Stroop task in Chi- nese character was used as target stimulus, block - design fMRI was used to acquire resource data. Group analysis （ control epoch minus task epoch） was performed for both tasks in both groups. Results Comparing with controls, the patients with hepatic cirrhosis had abnormal deactivation mode. The absence of posterior cingulate cortex （ PCC） and precuneus was present when performing incongruous word - reading task,deactivation of PCC, precuneus, and ventral medial prefrontal cortex were increased when performing incongruous colornaming task. Conclusion Cirrhosis patients have abnormal deactivation mode,the absence of PCC and precuneus is a sensitive not specific biomarker in detecting the brain changes of the patients with hepatic cirrhosis.