中文摘要：

核磁共振成像（MRI）是肿瘤诊断的重要手段，特别是各种造影剂的使用加速了临床应用范围。目前临床MRI检查所用各类造影剂如Gd—DTPA—BMA、Gd—DOTA等均为小分子造影剂，存在组织特异性低、体内停留时间短等缺点。构建具有组织特异性的新一代高效、低毒MRI造影剂成为材料界、医学界的研究热点之一。本文在综合最新文献的研究基础之上，重点关注含钆类造影剂在肿瘤靶向成像中的应用及发展。

英文摘要：

Magnetic resonance imaging （MRI） is an important technique of medical imaging for the tumor diagnosis, due to its high spatial and temporal resolutions and excellent soft tissue contrast, especially after the usage of various contrast agents. However, the current contrast agents for MRI, such as Gd-DTPA-BMA, Gd-DOTA etc.,are all small molecules, which are associated with the intrinsic drawbacks such as nonspecificity for the interesting tissue,rapid excretion in vivo. To address the above questions, the novel specific MRI contrast agents with high efficiency and low toxicity are thus becoming research hot spots in both material and medical fields. In this review,particular attention is paid on the recent progress of gadolinium-based MRI contrast agents for tumor targeting imaging by summarizing the relevant research papers. Both passive and active approach for tumor targeting imaging are involved in this review. The synthesis,principle and determined factors of MRI contrast agents for tumor targeting imaging and their in vitro or in vivo effects on the interesting tissue are discussed.