中文摘要：

更早，我们报导 ST239 是在中国的 15 年的占优势的 methicillin 抵抗的葡萄球菌 aureus (MRSA ) 克隆。在这研究， MRSA 种类 CN79 属于 ST239 并且从血孤立被用来决定整个染色体顺序。比较 genomics 分析在 MRSA CN79 和 25 定序的 S 之间被做。在 NCBI GenBank 数据库的 aureus。2,734 编码蛋白质的基因的一个总数在 MRSA CN79 染色体被识别，它带 11 抗菌素抵抗基因和 65 毒力基因。二 prophages phiCN79A 和象 phiNM3 一样在 MRSA CN79 染色体上被发现。MRSA CN79 带不在 25 定序的 S 的 30 特定的基因。aureus 染色体。他们中的大多数是 prophage 相关的基因。几抗菌素抵抗基因例如 -lactamase 和 ABC 类型 multidrug 运输系统基因，位于 genomic 岛 Sa。抗菌素抵抗基因例如 tet (M) ， ermA1，和 blaZ，也位于不同 transposons。毒力基因海，地图， hlb，和 sak 位于象 phiNM3 一样 prophage，外毒素基因被继续 genomic 岛 Sa。这些结果建议 ST239 MRSA 紧张由于活动基因元素的水平获得是普遍的响应环境选择压力怀有抗菌素抵抗基因和毒力基因，例如在进化期间的抗菌素和人的免疫系统。

英文摘要：

Earlier, we reported that ST239 was the 15-year predominant methicillin-resistant Staphylococcus aureus （MRSA） clone in China. In this study, MRSA strain CN79 belonging to ST239 and isolated from blood was used to determine the whole tive genomics analysis was genome sequence. Compara- done between MRSA CN79 and 25 sequenced S. aureus in the NCBI GenBank data- base. A total of 2,734 protein-encoding genes were iden- tified in the MRSA CN79 genome, which carries 11 antibiotic resistance genes and 65 virulence genes. Two prophages phiCN79A and phiNM3-1ike were found on the MRSA CN79 genome. MRSA CN79 carries 30 specific genes that are absent from the 25 sequenced S. aureus genomes. Most of them were prophage-related genes. Several antibiotic resistance genes, such as [3-1actamase and ABC-type multidrug transport system gene, were located on the genomic island vSal3. The antibiotic resis- tance genes, such as tet （M）, ermA1, and blaZ, were also located on different transposons. The virulence genes sea,map, hlb, and sak are located on phiNM3-1ike prophage and the exotoxin genes are carried on the genomic island vSaa. These results suggest that ST239 MRSA strains are widespread owing to horizontal acquisition of the mobile genetic elements harbored antibiotic resistance genes and virulence genes in response to environmental selective pressures, such as antibiotics and the human immune sys- tem during evolution.