中文摘要：

1-磷酸鞘氨醇（S1P）是一种具有多种生物活性的鞘脂类代谢产物,通过激活G蛋白偶联受体S1PRs调节重要的生理功能。S1P是维持上皮细胞和内皮细胞屏障功能重要的信号分子,S1P信号通路通过调节黏附连接和紧密连接组装、细胞骨架重排、黏着斑形成,发挥对屏障功能的调控作用,因此S1P信号通路可能成为改善急性肺损伤、炎症性肠病和败血症等疾病中屏障功能紊乱的新靶点。本文对S1P信号通路在上皮细胞和内皮细胞屏障功能调控中的作用及其在屏障功能破坏相关性疾病模型中的保护作用的研究进展进行综述,以期为开发治疗屏障功能破坏相关性疾病的新药提供理论参考。

英文摘要：

Sphingosine 1-phosphate （S1P） is a pleiotropic sphingolipid metabolite that has been shown to regu- late important physiological function by activation of its G-protein-coupled receptors S1PRs. S1 P has been identi- fied as an important signaling molecule in maintaining epithelial and endothelial barrier function. S1P signaling pathway is involved in epithelial and endothelial barrier function by regulation of adherens junction and tight junetion assembly, cytoskeletal reorganization, and foeal adhesion formation. Thus, S1P signaling pathway may become a novel therapeutic target for cell barrier dysfunction during some illnesses such as acute lung injury, inflammatory bowel disease and sepsis. In this review, the research progress of S1P signaling pathway in regulating epithelial and endothelial barrier function and the application of S1 P in barrier dysfunction-related diseases were summarized, so as to provide references for future research.