中文摘要：

为了克服壳聚糖只能溶于酸性水溶液的局限，对壳聚糖进行了化学修饰，通过引入磷酸基官能团，合成了可溶于中性水的磷酸化壳聚糖。以磷酸化壳聚糖和羧甲基壳聚糖为基材，采用聚电解质复合法制备了苦参碱／羧甲基壳聚糖／磷酸化壳聚糖纳米粒子水分散制剂。测试结果表明，纳米粒子的平均粒径为100-200nm，纳米粒子对苦参碱的负载率最高可达66．2％。

英文摘要：

Chitosan（CS） is modified by a chemical method to overcome its disadvantage which only dissolved in acid water. A water-soluble chitosan derivative Phosphorylation chitosan （PCS） is synthesized by introducing phosphonie group into chitosan. According to the static electric interaction between positive and negative polyelectrolyte, matrine/CMC/PCS namoparticle dispersible in water is prepared using PCS and carboxymethyl chitosan（CMC） as matrix materials. The results show that the particle size of the nanoparticles is 100-200nm, and the matrine load efficiency is up to 66.2%.