中文摘要：

目的 探讨在不同海拔的高原环境下，拉萨与那曲地区藏族青少年血清胰岛素生长因子Ⅰ（IGF-1）与碱性磷酸酶（ALP）的特点及其差异。方法 选取12～18岁世居拉萨和那曲地区的健康藏族青少年各336名，测定血清IGF-1与ALP的水平。结果拉萨组男性血清IGF-1高峰出现在14岁值为（327．50±58．26）μg／L，女性则在13岁值最高为（297．45±41．89）μg／L；那曲组男、女性IGF-1高峰年龄均较拉萨提前1年，峰值分别为（284．07．±53．72）μg／L，（271．90±24．09）μg／L。高峰期后，两组随年龄增长，血清IGF-1水平均下降（P〈0．05），同年龄同性比较，拉萨组血清IGF-1水平显著高于那曲组（P〈0．05）。两地血清ALP变化趋势均与IGF-1相似。结论 拉萨与那曲地区藏族青少年男、女性血清IGF-1、ALP水平均与年龄相关，两个海拔地区其规律有一定的差异。

英文摘要：

Objective To study the characteristics of Insulin - like growth factor Ⅰ （ IGF - 1 ） and Alkaline Phosphatase （ALP） in Tibetan adolescents living on Lhasa and Naqu. Methods 336 healthy Tibetan adolescents in Lhasa and Naqu aged 12 - 18 years were selected in the study. The levels of serum IGF - 1 and ALP were tested. Results The peak values of serum IGF - 1 was observed in Lhasa boys at 14 years （327.50±58. 261μg/L） and girls at 13 years （297.45 ±41. 891μg/L） . Whereas boys and girls in Naqu reached peak IGF - 1 levels approximately 1 year earlier. The peak values of serum 284. 07 ±53.72μg/L, 271.90 ±24. 091μg/L. Later the peak value, the levels of IGF - 1 declined with age. The levels of IGF - 1 in Lhasa were observably higher than those in Naqu at same age and sex group （P 〈 0.05） . Compared with IGF - 1, the change of serum ALP was similar. Conclusions Serum IGF - 1 and ALP in Tibetan adolescent in Lhasa and Naqu are closely associated with age, in both areas, the change of serum IGF - 1 and ALP were difference.