中文摘要：

目的对微小隐孢子虫中含WD40结构域的蛋白进行生物信息学分析，分析该蛋白家族的WD40结构并预测其功能，为微小隐孢子虫基因功能的研究提供一定的基础理论。方法通过隐孢子虫基因组数据库收集数据，获得微小隐孢子虫含WD40结构域蛋白家族的序列信息，搜索每个蛋白的CDD结构域并进行NCBIBLAST比对分析，确定为WD40结构域家族蛋白，分析结构域并预测功能。结果在C．parvum Iowa II中共搜索到50个含有WD40结构域的蛋白，其中cgd1_1930、cgd5_740和cgd4_3360含有CAF1C_H4-bd超家族结构，可能参与DNA修复和DNA复制过程；cgd4_260含有ACE1-sec16-like超家族，可能参与囊泡的形成和物质运输；cgd1_2600含有TAF5_NTD2结构域，可能参与蛋白与蛋白的相互作用。结论在微小隐孢子虫中，WD40蛋白家族不仅可能单独发挥作用，而且还能通过相互辅助、结合发挥其生物效应。

英文摘要：

Bioinformatics research about the WD40 domain contained protein family of Cryptosporidium parvum was conduct in this study, and then structure analysis of the WD40 domain and its function predictibn would provide some basic theory for Cryptosporidiurn parvurn gene function studies. Firstly, based on the data collection, we acquired WD40 domain contained protein family＇s sequences. Then the CDD domain search and alignment analysis were conducted through the NCBI for every protein to ensure that all of them were WD40 domain contained proteins. Lastly, we processed the domain analysis and functional prediction. So, we obtained 50 domain contained proteins of C. parvum Iowa II, and found that there were significant differences among their amino acid sequence length, molecular weight, isoelectric point, etc. And from domain analysis, egd1_1930, egd5_ 740 and egd4 3360 contains CAF1C_bd super family, which may be involved in DNA repair and replication; cgd4_260 contains ACE1-See16-like super family, which may be involved in vesicle formation and material transport; cgd1_ 2600 contains TAF5 NTD2 domain, which may involved in protein-protein interactions. It＇s suggested that the WD40 protein family may not only play a role in the interaction alone, but also exert their biological effects through it.