中文摘要：

目的：探讨慢性应激对大鼠牙周炎组织的影响,为临床治疗提供实验依据。方法：将大鼠随机分为正常对照组、牙周炎组和慢性应激牙周炎组3组。通过结扎大鼠牙周方法制备牙周炎模型后第3日开始建立慢性应激牙周炎大鼠模型。通过旷场实验和皮质醇实验检测大鼠应激状态。分别观察大鼠牙槽骨组织学改变及牙周各项指标检测。结果：牙周炎组及慢性应激牙周炎组的组织学及X线片检查发现牙周炎症明显,牙槽骨呈骨质疏松状态。对照组牙周组织无病理性改变;对照组观测指标与牙周炎组、慢性应激牙周炎组差别非常显著;牙周炎组与慢性应激牙周炎组相比牙周袋深度、牙龈指数有显著性差异。结论：慢性应激牙周炎组大鼠牙周的破坏程度较牙周炎组大鼠的牙周破坏程度深,慢性应激可能是牙周病的危险因素之一。

英文摘要：

Objective： To investigate the effect of chronic stress on the rat periodontitis. Methods： Rats were randomly divided into normal control group, periodontitis, chronic stress periodontitis group. The rats with periodontitis were obtained by ligaturing the neck of rat teeth with the stainless steel wire. Then periodontitis rats were used to establish the chronic psychological stress models. In order to observe reactions of rats by chronic stress , the open fieldtest and the concent rations of serum cortisol were measured. The periodontal clinical index and Xray examination of experimental tooth were recorded on 30 days. Results： In both experiment groups horizontal alveolar bone resorption could be observed by X 2 ray examination, and severe horizontal alveolar bone resorption appeared in chronic stress ligation group. The periodontitis appeared more severe with significant tooth mobility in chronic stress ligation group. Conclusion： chronic stress can aggravate the experimental periodontitis.This study showed the chronic stress may activity key signaling pathways in periodontitis.