中文摘要：

相比于超顺磁性纳米颗粒,具有涡旋磁畴的磁性纳米颗粒,由于独特的磁化闭合分布、较大的粒径尺寸及外加磁场中的磁化翻转特性,使得其兼具弱的颗粒间磁相互作用和更优异的磁学性能,在生物医学领域展现出了更好的应用优势和潜力.本综述结合近年来国内外对涡旋磁畴的研究及涡旋磁纳米颗粒在生物医学领域的报道,提出了一类新型的生物医用涡旋磁溶胶体系,并以涡旋磁氧化铁纳米盘和纳米环为例,介绍了涡旋磁纳米颗粒的化学合成,并着重论述了这类具有独特涡旋畴结构的纳米颗粒在磁共振成像、抗肿瘤治疗等生物医学应用上的最新研究进展.

英文摘要：

The application of magnetic nanoparticles on biomedicine has gained increased interest in recent years because of their unique magnetic properties such as superparamagnetism.However,magnetic nanoparticles possess these desirable features at the expense of particle size and magnetic properties such as reduced saturation magnetization and susceptibility,which in turn has affected its performance in bioapplication.In comparison with superparamagnettic nanoparticle,magnetic vortex nanoparticles with unique magnetic domain structure and relatively large particle size,has shown superior magnetic properties,which make them a promising candidate for diverse biomedical applications.In this article,we briefly review the progress on synthesis and biomedical application of magnetic vortex nanoparticles.In particular,magnetic vortex iron oxide nanodisks and nanorings are taken as typical examples to demonstrate the vortex domain structure and its magnetization reversal process.Benefits from their unique magnetic properties,these magnetic vortex nanoparticles have significantly improve the performance of MRI diagnostic and anti-tumor hyperthermia treatment as compared to currently available superparamagnetic iron oxides nanoparticles.Ultimately,the highly biocompatible magnetic vortex nanoparticles that we have introduced here can be a promising biomagnetic nanoplatform to construct a variety of high efficient nanoagent systems for biomedical application in the future.