中文摘要：

目的 评价肿瘤体积与淋巴结转移率（lymph nodes metastasis ratio,LNR）的比值作为Ⅲ期结直肠癌复发、转移指标的临床价值。方法 对2005年6月-2008年6月在本院普通外科行结直肠癌根治术的120例Ⅲ期结直肠癌患者临床资料进行分析,依据肿瘤是否复发、转移将120例结直肠癌患者分为无瘤生存组和肿瘤转移组,并进行随访分析。结果 单因素分析结果显示,阳性淋巴结数（P=0.037）、LNR（P=0.002）、N分期（P=0.045）和TN比值（P=0.038）与结直肠癌术后复发、转移具有相关性,差异有统计学意义。多因素分析结果显示TN比值（P=0.028）、LNR（P=0.029）和N分期（P=0.002）均为影响结直肠癌术后复发、转移的独立相关因素。结论 TN比值具有独立的近期预后作用,可作为Ⅲ期结直肠癌术后肿瘤复发、转移的重要评价指标。

英文摘要：

Objective To study the tumor volume and lymph node metastasis ratio as a recurrence and metastasis index of stage Ⅲ colorectal cancer （CRC）. Methods Clinical data about 120 stage Ⅲ CRC patients who underwent radical operation in our hospital from June 2005 to June 2008 were retrospectively analyzed. The patients were divided into tumor-free survival group and tumor metastasis group and followed up. Results Univariate analysis showed that the number of positive lymph nodes, lymph node ratio （LNR）, N stage and TN ratio were related with the recurrence and metastasis of stage Ⅲ CRC （P 〈 0.05）. Multivariate regression analysis showed that TN ratio, LNR and N stage were the independent factors for the recurrence and metastasis of stage Ⅲ CRC. Conclusion The TN ratio is an independent factor for the early prognosis of stage Ⅲ CRC, and can thus be used as an important index for the recurrence and metastasis of stage Ⅲ CRC after operation.