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中文摘要：
以七元瓜环为主体，抗癌药物甲氨蝶呤为客体，利用^1H NMR技术和紫外可见吸收光谱法研究了七元瓜环（Q[7]）对甲氨蝶呤（MTX）的分子识别作用，同时利用相溶解度及溶出度法考察了Q[7]对MTX溶解度及溶出度的影响。结果表明：MTX与Q[7]可形成2：1的主客体复合物，平衡常数为（9．55±0．37）×10^11L^2.Q[7]能增加MTX的溶解度及溶出度，并且Q[7]对MTX的增溶效果受体系的酸碱性影响。最后用^1H NMR法进一步证实了主客体的作用模式。
英文摘要：
In this paper, the interactions of cucurbit[ 7 ] uril（ Q [ 7 ] ） with anti-cancer drug MTX in different proton forms were investigated in details by UV absorption spectroscopy, phase solubility studies and ^1H NMR technique. The effects of pH on complex were also explored. The result showed that the inclusion ratio of Q [7] and MTX was 2： 1, and the formation constant was （9.55 ±0.37） × 10^11 L^2.mol-2. Moreover, solubility and dissolution of methotrexate increased as a function of Q[7] concentrations. The inclusion complex was further proved by ^1H NMR.
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