中文摘要：

目的：研究甜菜碱对高脂膳食诱导的脂代谢紊乱大鼠的血脂、肝脂和抗氧化能力的影响及其作用机制。方法：32只SD大鼠按血TC水平随机分成4组：高脂对照组和低、中、高3个剂量甜菜碱组。甜菜碱组在喂以高脂饲料的同时,分别给予不同剂量的甜菜碱灌胃,每天一次,持续4周。最终测定血脂、肝脂和抗氧化相关指标。结果：与高脂对照组相比,甜菜碱能使脂代谢紊乱大鼠的血清TG、LDL-C、肝脏TG、TC和肝脏指数显著下降,并升高血清SOD活性,降低肝脏MDA含量。结论：甜菜碱具有调节血脂、减轻肝脏脂质沉积和肝肿大、提高抗氧化能力的生物活性,可以预防脂代谢紊乱。

英文摘要：

Objective： To study the effect of betaine on serum lipid, hepatic lipid and antioxidation in rat of lipid metabolic disturbance induced by high-fat diet and its possible mechanism. Method： 32 SD rats were divided randomly into 4 groups based on serum TC level： high-fat diet group and 3 different doses of betaine groups. Betaine group rats were given by gavage once a day for 4 w with high-fat diet simultaneously.Serum lipid, hepatic lipid and antioxidative related indexes were determined. Results： Compared with high-fat diet group, serum TG, LDL-C, hepatic TG, TC and liver index decrease significantly. Serum SOD activity increases, while hepatic MDA content reduces. Conclusion： Betaine can regulate blood lipid level, improve hepatic lipid accumulation and hepatomegaly, and elevate antioxidative capacity. Thus it is able to prevent lipid metabolic disturbance.