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Apelin receptor signaling： a novel mechanism of endothelial cell polarization

ISSN号：1672-9145
期刊名称：《生物化学与生物物理学报：英文版》
时间：0
分类：Q463[生物学—生理学] Q516[生物学—生物化学]
作者机构：[1]Institute of Pharmacy and Pharmacology, Hunan Province Cooperative innovation Center for Molecular Target New Drugs Study, University of South China, Hengyang 421001, China, [2]Intensive Care Units of the Affiliated Nanhua Hospital, University of South China, Hengyang 421002, China
相关基金：This work was supported by the grants from the National Natural Science Foundation of China （81670265, 81270420, 81470434 and 81503074） and Zhengxiang Scholar Program of the University of South China （2014-004）, Hunan Province Education Department Science and Research Project （16C1392, 16C1395）, Hunan Provincial Science and Technology Project （2015R84040）, Administration of Traditional Chinese Medicine of Hunan Province （201578） and Health and Family planning commission of Hunan Province （B2015-48）.

作者： Hong Zhao[1], Pingbo Yao[2], Lanfang Li[1], Linxi Chen[1]

关键词：血管内皮细胞, APELIN, 极化机理, 信号, 受体, 细胞分化, 上皮细胞, 巨噬细胞

中文摘要：

细胞的极化对房间的许多类型普通，例如脉管的 endothelial 房间(EC ) ，巨噬细胞，和上皮的房间[1 ] 。一个单个房间有相反的方面和在方面对面连接的想象的轴的方向高度被协调。极化轴的这协作为机关的功能是必要的，命名平面房间极性(PCP )[2 ] 。房间细胞器，细胞骨架，或粘附建筑群什么时候沿着轴显示单向性的组织，发生。EC 连续地被暴露砍应力，和他们直接展出深刻词法改编，例如微导管的平面房间极化，延伸，和排列。另外，房间连接的状态和细胞骨架的动态重新整理为导致流动的 EC 极化的建立是重要的，它是维持脉管的动态平衡的一个重要决定因素。

英文摘要：

Cellular polarization is common to many types of cells, such as vascular endothelial cells （ECs）, macrophages, and epithelial cells . An individual cell has opposite sides and the directions of imaginary axes connecting opposite sides are highly coordinated.

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