目的采用威斯康星卡片分类测验(Wisconsin Card Sorting Test,WCST)分析海洛因依赖者认知功能损害情况。方法分别对60例住院脱毒治疗的海洛因依赖者与40例正常对照者进行WCST测验。结果与正常对照相比,海洛因依赖组WCST的总应答数(100.6±20.2)、完成分类数(5.4±1.4)、概念化水平百分数(87.9±13.0)%等测验值均较正常组差(海洛因依赖组60例,正常对照组40例,P〈0.05);男女海洛因依赖者WCST测验结果无显著差异;相关性分析发现海洛因依赖者年龄、受教育年限、用毒品年限、每日使用量与WCST测验结果之间没有显著相关性。结论海洛因依赖者存在认知功能损害,应对海洛因依赖者进行系统的康复治疗改善其认知功能预防复发。
Objective: To assess the cognitive impairment in the patients with heroin dependence. Methods: 60 patients with heroin dependence conducted Wisconsin card sorting test (WCST) during inpatient detoxification and 40 normal controls conducted same test. Results:Significant differences were found between the two groups in the following areas (60 patients with heroin dependence, 40 normal controls, P 〈 0.05 ) : number of total responses ( 100. 6 ± 20.2 ), number of categories (5.4 ± 1.4 ), percentages of conceptive level (87.9± 13.0)%. However no differences were found between male and female heroin dependent patients in these aspects ( P 〉 0.05 ). The study did not found that the severity of cognitive impairment correlated with years of heroin dependence, quantity of heroin use ( P 〉 0. 05 ). Conclusion: Patients with heroin dependence present cognitive impairments that can be detected by WCST. Therefore a comprehensive drug rehabilitation program which target on improving cognition is needed to improve their cognitive function and prevent relapse for heroin dependent patients.