中文摘要：

脂肪组织脂蛋白脂酶（LPL）受血管生成素样蛋白的调节进而影响脂肪能的储存及供能,心肌LPL受过氧化物酶体增殖物激活受体和腺苷酸活化蛋白激酶的调节进而影响心脏供能不足时对游离脂肪酸的摄取,而巨噬细胞LPL受微小RNA的调节进而抑制泡沫细胞的形成。不同组织LPL的调节受到多种调节因子影响,且对机体影响不同。本文主要综述LPL在脂肪组织、心肌和巨噬细胞的调节,以及相关蛋白对LPL活性的影响,以期进一步明确LPL在各种组织中的作用和意义。

英文摘要：

Adipose tissue lipoprotein lipase （LPL） is regulated by angiopoietin-like protein and influences the storage and energy supply of adipose energy.Myocardial LPL is regulated by peroxisome proliferator-activated receptor and adenosine monophosphate activated protein kinase and influences the uptake of free fatty acids in the absence of cardiac energy supply.Macrophage LPL is regulated by microRNA and inhibits the formation of foam cells.The regulation of LPL in various tissues is influenced by many factors,and the effects are different.In this paper,we reviewed the regulation of LPL in adipose tissue,myocardium and macrophages,and the effects of related proteins on LPL activity,in order to further clarify the role and significance of LPL in various tissues.