中文摘要：

目的：观察利培酮与氯氮平对正常大鼠及胰岛素抵抗大鼠糖代谢的影响。方法：雄性Wistar大鼠60只,随机分为A组（正常对照组）、B组（利培酮组）、C组（氯氮平组）、D组（胰岛素抵抗组）、E组（胰岛素抵抗＋利培酮组）和F组（胰岛素抵抗＋氯氮平组）,每组各12只。以高糖、高脂饲料诱导法建立大鼠胰岛素抵抗模型。12周后以口服糖耐量实验葡萄糖曲线下面积（AUC）、早期相胰岛素分泌指数（ΔI30/ΔG30）、正糖钳夹实验葡萄糖输注率（GIR）及免疫组化法检测利培酮、氯氮平对正常及胰岛素抵抗大鼠血糖、胰岛素抵抗及胰岛素分泌的影响。结果：利培酮及氯氮平对正常大鼠糖耐量AUC无明显影响（t=0.638,1.021;P均〉0.05）;利培酮及氯氮平分别上调胰岛素抵抗大鼠糖耐量AUC（t=2.029,3.305;P〈0.05或P〈0.01）。利培酮对正常大鼠胰岛素抵抗无明显影响（t=1.832,P=0.072）,利培酮、氯氮平分别下调胰岛素抵抗大鼠GIR（t=2.061,3.568;P〈0.05或P〈0.001）。利培酮对正常大鼠ΔI30/ΔG30无明显影响（t=1.972,P=0.058）,利培酮及氯氮平明显下调胰岛素抵抗大鼠ΔI30/ΔG30（t=2.721,3.696;P〈0.01或P〈0.001）。利培酮对正常及胰岛素抵抗大鼠胰岛素染色积分下光密度均无明显影响（t=0.086,0.685;P均〉0.05）,氯氮平下调胰岛素抵抗大鼠胰岛素染色积分下光密度（t=3.728,P〈0.001）。结论：利培酮对正常大鼠葡萄糖敏感性及胰岛功能影响较小,氯氮平、利培酮对胰岛素抵抗大鼠的胰岛素敏感性及胰岛素分泌有一定影响。

英文摘要：

Objective：To investigate the effects of risperidone and clozapine on glucose metabolism in normal and insulin resistance（IR） rats.Method：Sixty male Wistar rats were divided randomly into six groups：normal rat group（n=12）,normal rat＋risperidone group（n=12）,normal rat＋clozapine group（n=12）,IR rat group（n=12）,IR rat＋risperidone group（n=12）and IR rat＋clozapine group（n=12）.The IR rats model was developed by feeding high diet containing high concentration of sugar and fat.After intragastric administration for 12 weeks,the glucose area under curve（AUC） and early stage insulin secretion index（ΔI30/ΔG30） of oral glucose tolerance test（OGTT）,the glucose infusion rate（GIR） of euglycaemic-hyperinsulinaemic clamp technique were applied to detect the level of blood sugar,the intensity of insulin resistance as well as the insulin level of the rats.Results：Both risperidone and clozapine show little influence on glucose AUC of OGTT in normal rats（t=0.638,1.021;all P0.05）,meanwhile,the AUC of OGTT in both groups of rats treated with risperidone and clozapine were improved compared with of normal group（t=2.029,3.305;P0.05 or P0.01）.Risperidone has been shown little effect on GIR by means of euglycaemic-hyperinsulinaemic clamp in normal rats（t=1.832,P=0.072）,and both risperidone and clozapine have been shown to down-regulate the GIR in IR rats（t=2.061,3.568;P0.05 or P0.001）.Risperidone has been proved to have little interference on ΔI30/ΔG30 in normal rats（t=1.972,P=0.058）,both the risperidone and clozapine down-regulate the ΔI30/ΔG30 in IR rats（t=2.721,3.696;P0.01 or P0.001） with no effect on integral optical density（IOD） of islet insulin staining in normal and IR rats（t=0.086,0.685;all P0.05） by clozapine.And clozapine decrease IOD of islet insulin staining in IR rats（t=3.728,P0.001）.Conclusion：Our experiments did not observe any impact imposed by risperidone on IR and insulin section in normal rats,although both risperidone and