中文摘要：

目的：观察枳术颗粒对慢性萎缩性胃炎大鼠的保护作用。方法：建立慢性萎缩性胃炎的大鼠模型,分为正常组、模型组,胃复春组,枳术颗粒5g/kg组、10g/kg组、20g/kg组。用Western blotting、免疫组化及Real time-PCR方法检测胃组织中TFF1蛋白及基因的表达。结果：与正常组比较,模型组大鼠胃粘膜腺腔结构不完整,炎细胞浸润粘膜全层,腺体数目减少消失,体重增长率降低,TFF1蛋白及mRNA表达明显降低。与模型组比较,枳术颗粒5g/kg、10g/kg、20g/kg及胃复春0.86g/kg大鼠体重增长率均显著增加,枳术颗粒组TFF1蛋白及mRNA表达增高明显;与胃复春组比较,枳术颗粒5g/kg、10g/kg、20g/kg大鼠体重增长率明显增加,且TFF1蛋白表达增加,而枳术颗粒10g/kg、20g/kg TFF1mRNA表达明显增高。结论：枳术颗粒可加快大鼠体重增加,使CAG大鼠胃粘膜组织得到改善和恢复,其机制可能是通过上调胃粘膜保护因子TFF1的表达而起到预防及治疗作用。

英文摘要：

Objective ：To observe the effect of Zhizhu granula on the rat model with chronic atrophic gastritis. Methods ：To estabhsh and improve the rat model with chronic atrophic gastritis, and dividing into model group, Weifuchun group, Zhizhu granula 0.5g/ml group,Zhizhu granula 1g/ml group,Zhizhu granula 2g/ml group. The RNA and protein expression of TFFI were deteced by Real time-PCR, Western Blotting and immunohistochemicalmethod. Results： Compared with the normal group, model group of rat gastric mucosa gland cavity structure is not complete, with obvious infiltration of inflammatory cell , significant decreasing in weight growth rate , the expression of TFF1 protein and mRNA were significantly decreased; Compared with the model group, Zhizhu granula 5g/kggroup, 10g/kggroup,20g/kg group and WeiFuChun O. 86g/kg group were significantly increased CAG rats body weight growth rate （ P 〈 0.01 ）, Zhizhu granula groups significantly increased rat gastric tissue TFF1 protein and mRNA expression （P 〈 0.01 ） ;Compared with the WeiFuChun group, Zhizhu granula groups were signifi-cantly increased CAG rats body weight growth rate （ P 〈 O. 01 ）, Zhizhu granules groups also increased the expression of rat gastric tissue TFF1 protein （ P 〈 0.01 ）, Zhizhu granula 10g/kg group and Zhizhu granula 20g/g group increased the expression of rat gastric tissue TFFI mRNA （P 〈 0.01 ）. Conehlsion：The Zhizhu grantlla particle therapy can increase the growth of the body weight of rats, and can improve stomach tissue pathological morphology. The Zhizhu granula particles can increase the expression of TFF1 which is the gastric mucosal protection factor of CAG model.