中文摘要：

人的内长的 retrovirus W env (HERV-W env ) 在象精神分裂症和多重硬化(MS ) 那样的许多 neuropsychological 疾病起一个关键作用。这些疾病被免疫学的反应在中央神经系统(CNS ) 伴随。Microglia 是在能生产 gasotransmitter 氮的氧化物的大脑发炎的重要 immunocytes (没有) 。没有不仅在 neuronal 房间的功能起一个作用而且参予各种各样的 neuropsychological 疾病的致病。在这研究，我们报导了在他们是有 HERV-W env 的 transfected 以后，没在 CHME-5 microglia 房间增加生产。而且， HERV-W env 增加了人的可诱导的氮的氧化物 synthase (hiNOS ) 的表达式和函数并且提高了 hiNOS 的倡导者活动。Microglial 移植也被提高。这些数据表明 HERV-W env 可能贡献在由从这调整可诱导的 NOS. 结果的表达式的 neuropsychological 混乱的生产和 microglial 移植能力都不学习的增加可能为 neuropsychological 疾病的处理导致新奇目标的鉴定，包括 neuroinflammatory 疾病，击，和 neurodegenerative 疾病。

英文摘要：

Human endogenous retrovirus W env（HERV-W env） plays a critical role in many neuropsychological diseases such as schizophrenia and multiple sclerosis（MS）. These diseases are accompanied by immunological reactions in the central nervous system（CNS）. Microglia are important immunocytes in brain inflammation that can produce a gasotransmitter - nitric oxide（NO）. NO not only plays a role in the function of neuronal cells but also participates in the pathogenesis of various neuropsychological diseases. In this study, we reported increased NO production in CHME-5 microglia cells after they were transfected with HERV-W env. Moreover, HERV-W env increased the expression and function of human inducible nitric oxide synthase（hi NOS） and enhanced the promoter activity of hi NOS. Microglial migration was also enhanced. These data revealed that HERV-W env might contribute to increase NO production and microglial migration ability in neuropsychological disorders by regulating the expression of inducible NOS. Results from this study might lead to the identification of novel targets for the treatment of neuropsychological diseases, including neuroinflammatory diseases, stroke, and neurodegenerative diseases.