中文摘要：

目的 探讨ⅠA2~ⅡA2期宫颈癌盆腔淋巴结转移与主骶韧带浸润的关系。方法 收集南方医科大学南方医院等5家医院2004-2014年因宫颈癌行广泛性子宫切除术加淋巴结切除术的2982例患者的临床、病理资料,其中855例符合纳入标准,进行回顾性分析。结果 （1）ⅠA2~ⅡA2期宫颈癌主骶韧带浸润率（3.86%）明显低于盆腔淋巴结转移率（21.05%）。（2）盆腔淋巴结转移与主骶韧带浸润呈正相关（r=0.254,P=0.000）,盆腔淋巴结阳性ⅠA2~ⅡA2期宫颈癌患者主骶韧带浸润率（13.9%）明显高于盆腔淋巴结阴性者（1.3%）（χ2=55.147,P=0.000）。（3）盆腔淋巴结转移预测主骶韧带浸润灵敏度72.7%、特异度81.0%、阳性预测值13.3%、阴性预测值98.5%。（4）盆腔淋巴结转移数目不同（0、1、2、≥3个）,主骶韧带整体浸润率明显不同（P=0.000）,随着盆腔淋巴结转移数目增加,主骶韧带浸润率明显增高。（5）主骶韧带浸润与盆腔淋巴结转移具有同侧性趋势（χ2=31.220,P=0.000）。结论 ⅠA2~ⅡA2期宫颈癌主骶韧带浸润与盆腔淋巴结转移具有正相关性和有同侧转移的趋势,盆腔淋巴结转移对主骶韧带浸润具有阴性预测价值。

英文摘要：

Objective To analyse the correlation of the invasion of cardinal and uterosacral ligaments（CL/USL） withmetasitasis of pelvic lymph node in ⅠA2~ⅡA2 cervical cancer.Methods Retrospective analysis was performed onpatients with cervical cancer who were perofermed radical hysterectomy and the data of cervical biopsy and radicalhysterectomy and pelvic lymph node resection were cdlected form Janurary 2004 to December 2014 at Nanfang Hospitaland four other hospitals.Results（1） The invasion rate of CL/USL was 3.86%,which is significantly lower than the rateof pelvic lymph node metastasis（21.05%）.（2） The invasion rate of CL/USL was positively correlated with the rate ofpelvic lymph node metastasi（r= 0.254,P= 0.000）.The invasion rate of ligaments of pelvic lymph node positive group（13.9%） was significantly higher than the group of negative pelvic lymph node（1.3%）（χ2=55.147,P=0.000）.（3）Thesensitivity,specificity,positive predictive value and negative predictive value of pelvic lymph node metastasespredicted by the invasion of CL/USL was 72.7%,81.0%,13.3% and 98.5% respectively.（4） With different number ofpelvic lymph node metastasis（0,1,2,3 or higher）,the invasion rate of CL/USL was significantly different（P= 0.000）,and with the increase of number of pelvic lymph node metastasis,the invasion rate of CL/USL increased obviously.（5）The invasion of CL/USL and pelvic lymph node metastasis ligament had ipsilateral trend（χ2=31.220,P=0.000）.Conclusion ligaments has positively correlation and ipsilateral trendwith the metastasis of pelvic lymph node in ⅠA2~ⅡA2stage cervical cancer.The metastasis of pelvic lymphnode has negative predictive value to the invasion of USL/CL.