中文摘要：

目的：研究风尾草对雷公藤甲素的减毒作用以及免疫抑制和抗炎镇痛活性的影响。方法：通过比较雷公藤甲素单用及与凤尾草联用对小鼠急性毒性、肝组织形态和大鼠肝功能的影响来评价凤尾草对雷公藤甲素的减毒作用；采用噻唑兰（MTT）法测定雷公藤甲素单用及与凤尾草联用对小鼠T、B淋巴细胞增殖的影响；采用二甲苯致小鼠耳廓肿胀实验研究凤尾草对雷公藤甲素抗炎作用的影响；采用热板法和扭体法研究凤尾草对雷公藤甲素镇痛作用的影响。结果：雷公藤甲素联用凤尾草后LD50增大了约1倍，肝细胞损伤明显减轻。ALT和AST明显降低；雷公藤甲素单用及与凤尾草联用均能显著抑制小鼠T、B淋巴细胞的增殖和二甲苯致小鼠耳廓肿胀，并均有明显的镇痛作用，但两者作用效果差异无显著性。结论：联合运用凤尾草可降低雷公藤甲素毒性并基本保持其免疫抑制和抗炎镇痛活性。

英文摘要：

OBJECtIVE To investigate the toxicities and activities of triptolide combined with Pteris muhifida Poir.. METHODS Toxicity of triptolide combined with Pteris multifida were evaluated with LD50, morphology of hepatic tissue and liver function. Activities of triptolide combined with Pteris multifida were evaluated with growth inhibiting effects of both T and B lymphoeytes detected by MTT assay, swelling of mouse auricle caused by dimethyl benzene and analgesic effect detected by hot plate test and writhing method. RESULTS The LD50, of triptolide was significantly increased meanwhile ALT and AST were significantly decreased while combined with Pteris multifida. Both triptolide and triptolide combined with Pteris muhifida can significantly inhibit the growth of T and B lymphocytes, swelling of mouse auricle caused by dimethyl benzene and alleviate pain inhot plate test of mouse. CONCLUSION Pteris multifida can reduce the toxicity of triptolide and maintain its immune suppression, antiinflammatory and analgesic activities.