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中文摘要：
氮杂环丙烷作为环氧丙烷的结构类似物,表现出与后者类似的亲电反应性[1],是重要的有机合成中间体.近十年来,通过氮宾与双键的加成合成手性氮杂环丙烷也得到了一定的发展[2,3],我们用以蒽为骨架的新型手性双噁唑啉配体AnBox(1)对一系列α,β-不饱和酮进行高对映选择性地氮杂环丙烷化,反应的收率可以达到92%,ee值达到＞99%,远高于文献中报道的ee值(86%)[4].同时通过与Evans的配体Box(2)比较发现,从相同构型的氨基醇得到的手性双噁唑啉催化相同底物的氮杂环丙烷化时得到相反绝对构型的产物,这两个不同骨架的配体形成的手性环境的差异对这种立体构型的翻转起着重要作用.……
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