中文摘要：

目的 ：利用3130遗传基因测序仪的电泳图谱分析江苏人群D21S11、D6S1043、Penta E、PGA、D2S1338、D11S51、D19S433、D12S391、CSF1PO、D3S1358、Penta D、VWA、D13S317、THO1、TPOX、D8S1179、D16S539、D5S818、D7S820 19个STR基因座多态性分布,并计算该19个基因座的基因频率、个体鉴别能力、无偏倚期望杂合度、多态性信息总量和非父排除率。方法：利用PCR扩增,产物通过3130测序仪毛细管电泳。读出数据后用分析软件进行分析。结果：19个STR位点中Penta E的个体鉴别能力值和非父排除率值最高,19个STR位点的累积非父排除率达0.9999以上。结论：通过大量的样本实验和等位基因频率的统计,得出了更加客观的等位基因多态性数据,为江苏地区亲权鉴定的判定提供更加客观的依据。

英文摘要：

Objective：To analyze the polymorphism distributions of 19 STR loci including D21S11,D6S1043,Penta E,PGA,D2S1338,D11S51,D19S433,D12S391,CSF1PO,D3S1358,Penta D,VWA,D13S317,THO1,TPOX,D8S1179,D16S539,D5S818 and D7S820 in Jiangsu population,and calculate their gene frequency（P）,power of discrimination（DP）,unbiased expected heterozygosity（H）,polymorphism information content（PIC）,and probability of paternity exclusion（PE）.Methods：Capillary electrophoresis was detected using PCR via 3130 sequencing.Analysis software was used to analyze data.Results：The DP value and PE value of Penta E were the highest in the 19 STR sites.The cumulate PE of the 19 STR loci was above 0.9999.Conclusion：Objective allelic polymorphism data were obtained from a large number of sample experiments and allele frequency,which provide an objective basis for identification in disputed paternity of Jiangsu area.